| 1 |  |  | """Functions for shortening GO names.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 2 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 3 |  |  | __copyright__ = "Copyright (C) 2016-2017, DV Klopfenstein, H Tang, All rights reserved." | 
            
                                                                                                            
                            
            
                                    
            
            
                | 4 |  |  | __author__ = "DV Klopfenstein" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 5 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 6 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 7 |  |  | class ShortenText(object): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 8 |  |  |     """Shorten text for concise display.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 9 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 10 |  |  |     greek2hex = {'alpha':0x03b1, 'beta':0x03b2, 'gamma':0x03b3, 'delta':0x03b4} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 11 |  |  |     greek2tex = {'alpha':r'$\alpha$', 'beta':r'$\beta$', 'gamma':r'$\gamma$', 'delta':r'$\delta$'} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 12 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 13 |  |  |     def __init__(self): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 14 |  |  |         self.greek2uni = {g:unichr(h).encode('utf-8') for g, h in self.greek2hex.items()} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 15 |  |  |         self.keep = [ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 16 |  |  |             "defense response to protozoan", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 17 |  |  |             "defense response to bacterium", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 18 |  |  |             "cellular response to interferon-beta", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 19 |  |  |             "defense response to virus", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 20 |  |  |             "response to interferon-gamma", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 21 |  |  |             "innate immune response", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 22 |  |  |             "inflammatory response", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 23 |  |  |             "response to virus", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 24 |  |  |             "immune response"] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 25 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 26 |  |  |     def get_short_plot_name(self, goobj): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 27 |  |  |         """Shorten some GO names so plots are smaller.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 28 |  |  |         name = goobj.name | 
            
                                                                                                            
                            
            
                                    
            
            
                | 29 |  |  |         if self._keep_this(name): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 30 |  |  |             return self.replace_greek(name) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 31 |  |  |         name = name.replace("cellular response to chemical stimulus", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 32 |  |  |                             "cellular rsp. to chemical stim.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 33 |  |  |         depth = goobj.depth | 
            
                                                                                                            
                            
            
                                    
            
            
                | 34 |  |  |         if depth > 1: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 35 |  |  |             name = name.replace("regulation of ", "reg. of ") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 36 |  |  |             name = name.replace("positive reg", "+reg") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 37 |  |  |             name = name.replace("negative reg", "-reg") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 38 |  |  |             name = name.replace("involved in", "in") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 39 |  |  |         if depth > 2: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 40 |  |  |             name = name.replace("antigen processing and presentation", "a.p.p") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 41 |  |  |             name = name.replace("MHC class I", "MHC-I") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 42 |  |  |             if depth == 4: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 43 |  |  |                 if goobj.id == "GO:0002460": | 
            
                                                                                                            
                            
            
                                    
            
            
                | 44 |  |  |                     before = " ".join([ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 45 |  |  |                         "adaptive immune response based on somatic recombination of", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 46 |  |  |                         "immune receptors built from immunoglobulin superfamily domains"]) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 47 |  |  |                     name = name.replace( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 48 |  |  |                         before, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 49 |  |  |                         "rsp. based on somatic recombination of Ig immune receptors") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 50 |  |  |             if depth > 3: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 51 |  |  |                 name = name.replace("signaling pathway", "sig. pw.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 52 |  |  |                 name = name.replace("response", "rsp.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 53 |  |  |                 name = name.replace("immunoglobulin superfamily domains", "Ig domains") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 54 |  |  |                 name = name.replace("immunoglobulin", "Ig") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 55 |  |  |             if depth > 4: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 56 |  |  |                 name = name.replace("production", "prod.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 57 |  |  |             if depth == 6 or depth == 5: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 58 |  |  |                 name = name.replace("tumor necrosis factor", "TNF") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 59 |  |  |         name = self.replace_greek(name) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 60 |  |  |         return name | 
            
                                                                                                            
                            
            
                                    
            
            
                | 61 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 62 |  |  |     def shorten_go_name_ptbl1(self, name): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 63 |  |  |         """Shorten GO name for tables in paper.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 64 |  |  |         if self._keep_this(name): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 65 |  |  |             return name | 
            
                                                                                                            
                            
            
                                    
            
            
                | 66 |  |  |         name = name.replace("negative", "neg.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 67 |  |  |         name = name.replace("positive", "pos.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 68 |  |  |         name = name.replace("response", "rsp.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 69 |  |  |         name = name.replace("regulation", "reg.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 70 |  |  |         name = name.replace("antigen processing and presentation", "app.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 71 |  |  |         return name | 
            
                                                                                                            
                            
            
                                    
            
            
                | 72 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 73 |  |  |     def shorten_go_name_ptbl3(self, name, dcnt): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 74 |  |  |         """Shorten GO description for Table 3 in manuscript.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 75 |  |  |         if self._keep_this(name): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 76 |  |  |             return name | 
            
                                                                                                            
                            
            
                                    
            
            
                | 77 |  |  |         name = name.replace("positive regulation of immune system process", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 78 |  |  |                             "+ reg. of immune sys. process") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 79 |  |  |         name = name.replace("positive regulation of immune response", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 80 |  |  |                             "+ reg. of immune response") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 81 |  |  |         name = name.replace("positive regulation of cytokine production", | 
            
                                                                                                            
                            
            
                                    
            
            
                | 82 |  |  |                             "+ reg. of cytokine production") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 83 |  |  |         if dcnt < 40: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 84 |  |  |             name = name.replace("antigen processing and presentation", "a.p.p.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 85 |  |  |         if dcnt < 10: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 86 |  |  |             name = name.replace("negative", "-") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 87 |  |  |             name = name.replace("positive", "+") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 88 |  |  |             #name = name.replace("tumor necrosis factor production", "tumor necrosis factor prod.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 89 |  |  |             name = name.replace("tumor necrosis factor production", "TNF production") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 90 |  |  |         if dcnt < 4: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 91 |  |  |             name = name.replace("regulation", "reg.") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 92 |  |  |             name = name.replace("exogenous ", "") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 93 |  |  |             name = name.replace(" via ", " w/") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 94 |  |  |             name = name.replace("T cell mediated cytotoxicity", "cytotoxicity via T cell") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 95 |  |  |         name = name.replace('involved in', 'in') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 96 |  |  |         name = name.replace('-positive', '+') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 97 |  |  |         return name | 
            
                                                                                                            
                            
            
                                    
            
            
                | 98 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 99 |  |  |     def replace_greek(self, name): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 100 |  |  |         """Replace text representing greek letters with greek letters.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 101 |  |  |         name = name.replace('gamma-delta', 'gammadelta') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 102 |  |  |         name = name.replace('interleukin-1 beta', 'interleukin-1beta') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 103 |  |  |         greek_present = False | 
            
                                                                                                            
                            
            
                                    
            
            
                | 104 |  |  |         for greek_txt, uni in self.greek2uni.items(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 105 |  |  |             if greek_txt in name: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 106 |  |  |                 greek_present = True | 
            
                                                                                                            
                            
            
                                    
            
            
                | 107 |  |  |                 name = name.replace(greek_txt, "{B}".format(B=uni)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 108 |  |  |         if greek_present is True: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 109 |  |  |             name = unicode(name, 'utf-8') # For writing to xlsx | 
            
                                                                                                            
                            
            
                                    
            
            
                | 110 |  |  |         return name | 
            
                                                                                                            
                                                                
            
                                    
            
            
                | 111 |  |  |  | 
            
                                                                        
                            
            
                                    
            
            
                | 112 |  |  |     def replace_greek_tex(self, name): | 
            
                                                                        
                            
            
                                    
            
            
                | 113 |  |  |         """Replace text representing greek letters with greek letters.""" | 
            
                                                                        
                            
            
                                    
            
            
                | 114 |  |  |         name = name.replace('gamma-delta', 'gammadelta') | 
            
                                                                        
                            
            
                                    
            
            
                | 115 |  |  |         name = name.replace('interleukin-1 beta', 'interleukin-1beta') | 
            
                                                                        
                            
            
                                    
            
            
                | 116 |  |  |         # greek_present = False | 
            
                                                                        
                            
            
                                    
            
            
                | 117 |  |  |         for greek_txt, tex in self.greek2tex.items(): | 
            
                                                                        
                            
            
                                    
            
            
                | 118 |  |  |             if greek_txt in name: | 
            
                                                                        
                            
            
                                    
            
            
                | 119 |  |  |                 # greek_present = True | 
            
                                                                        
                            
            
                                    
            
            
                | 120 |  |  |                 name = name.replace(greek_txt, "{B}".format(B=tex)) | 
            
                                                                        
                            
            
                                    
            
            
                | 121 |  |  |         # if greek_present is True: | 
            
                                                                        
                            
            
                                    
            
            
                | 122 |  |  |         #     name = texcode(name, 'utf-8') # For writing to xlsx | 
            
                                                                        
                            
            
                                    
            
            
                | 123 |  |  |         return name | 
            
                                                                                                            
                            
            
                                    
            
            
                | 124 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 125 |  |  |     def shorten_go_name_all(self, name): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 126 |  |  |         """Shorten GO name for tables in paper, supplemental materials, and plots.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 127 |  |  |         name = self.replace_greek(name) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 128 |  |  |         name = name.replace("MHC class I", "MHC-I") | 
            
                                                                                                            
                            
            
                                    
            
            
                | 129 |  |  |         return name | 
            
                                                                                                            
                            
            
                                    
            
            
                | 130 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 131 |  |  |     def _keep_this(self, name): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 132 |  |  |         """Return True if there are to be no modifications to name.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 133 |  |  |         for keep_name in self.keep: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 134 |  |  |             if name == keep_name: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 135 |  |  |                 return True | 
            
                                                                                                            
                            
            
                                    
            
            
                | 136 |  |  |         return False | 
            
                                                                                                            
                            
            
                                    
            
            
                | 137 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 138 |  |  |     #@staticmethod | 
            
                                                                                                            
                            
            
                                    
            
            
                | 139 |  |  |     #def _shorten_go_name(name): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 140 |  |  |     #    name = name.replace(' and ', ' & ') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 141 |  |  |     #    if gont.dcnt < 15: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 142 |  |  |     #        name = name.replace('MHC class I', 'MHC-I') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 143 |  |  |     #        name = name.replace('antigen processing & presentation', 'a. p. p.') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 144 |  |  |     #        name = name.replace('positive regulation', 'pos. reg.') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 145 |  |  |     #    elif gont.depth > 2: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 146 |  |  |     #        name = name.replace(' & presentation', ' & pres.') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 147 |  |  |     #    return name | 
            
                                                                                                            
                            
            
                                    
            
            
                | 148 |  |  |  | 
            
                                                                                                            
                                                                
            
                                    
            
            
                | 149 |  |  | # Copyright (C) 2016-2017, DV Klopfenstein, H Tang, All rights reserved. | 
            
                                                        
            
                                    
            
            
                | 150 |  |  |  |