| 1 |  |  | """Creates and manages edges from one GO term to another GO term.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 2 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 3 |  |  | __copyright__ = "Copyright (C) 2016-2018, DV Klopfenstein, H Tang, All rights reserved." | 
            
                                                                                                            
                            
            
                                    
            
            
                | 4 |  |  | __author__ = "DV Klopfenstein" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 5 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 6 |  |  | from collections import defaultdict | 
            
                                                                                                            
                            
            
                                    
            
            
                | 7 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 8 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 9 |  |  | def get_edgesobj(gosubdag, **kws): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 10 |  |  |     """Return specfied GoSubDag initialization object.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 11 |  |  |     # Keyword args (kws): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 12 |  |  |     #     1. dst_srcs_list  Used for edges pruned such that only GO terms | 
            
                                                                                                            
                            
            
                                    
            
            
                | 13 |  |  |     #                       are retained which are between the sets of dst & srcs. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 14 |  |  |     #     2  traverse_parent & traverse_child | 
            
                                                                                                            
                            
            
                                    
            
            
                | 15 |  |  |     #                       Used to generate a GoSubDag with all parent terms and/or | 
            
                                                                                                            
                            
            
                                    
            
            
                | 16 |  |  |     #                       all child terms, without pruning any paths. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 17 |  |  |     # Call function, get_edgesobj, with: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 18 |  |  |     #     get_edgesobj(go2obj, dst_srcs_list=...) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 19 |  |  |     # Or any of: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 20 |  |  |     #     get_edgesobj(go2obj, go_sources=...) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 21 |  |  |     #     get_edgesobj(go2obj, go_sources=..., traverse_parent=...,) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 22 |  |  |     #     get_edgesobj(go2obj, go_sources=..., traverse_child=...,) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 23 |  |  |     #     get_edgesobj(go2obj, go_sources=..., traverse_parent=..., traverse_child=...,) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 24 |  |  |     edgeobj = _get_edgesobj(gosubdag, **kws) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 25 |  |  |     rm_gos = kws.get('rm_gos') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 26 |  |  |     if rm_gos is not None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 27 |  |  |         edgeobj.rm_gos(rm_gos) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 28 |  |  |     return edgeobj | 
            
                                                                                                            
                            
            
                                    
            
            
                | 29 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 30 |  |  | def _get_edgesobj(gosubdag, **kws): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 31 |  |  |     """Return specfied GoSubDag initialization object.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 32 |  |  |     # Keyword args (kws): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 33 |  |  |     #     1. dst_srcs_list  Used for edges pruned such that only GO terms | 
            
                                                                                                            
                            
            
                                    
            
            
                | 34 |  |  |     #                       are retained which are between the sets of dst & srcs. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 35 |  |  |     #     2  traverse_parent & traverse_child | 
            
                                                                                                            
                            
            
                                    
            
            
                | 36 |  |  |     #                       Used to generate a GoSubDag with all parent terms and/or | 
            
                                                                                                            
                            
            
                                    
            
            
                | 37 |  |  |     #                       all child terms, without pruning any paths. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 38 |  |  |     # Call function, get_edgesobj, with: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 39 |  |  |     #     get_edgesobj(go2obj, dst_srcs_list=...) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 40 |  |  |     # Or any of: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 41 |  |  |     #     get_edgesobj(go2obj, go_sources=...) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 42 |  |  |     #     get_edgesobj(go2obj, go_sources=..., traverse_parent=...,) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 43 |  |  |     #     get_edgesobj(go2obj, go_sources=..., traverse_child=...,) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 44 |  |  |     #     get_edgesobj(go2obj, go_sources=..., traverse_parent=..., traverse_child=...,) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 45 |  |  |     dst_srcs_list = kws.get('dst_srcs_list', None) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 46 |  |  |     if dst_srcs_list is not None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 47 |  |  |         return EdgesPath(gosubdag, dst_srcs_list) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 48 |  |  |     return EdgesRelatives(gosubdag, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 49 |  |  |                           kws.get('traverse_parent', True), | 
            
                                                                                                            
                            
            
                                    
            
            
                | 50 |  |  |                           kws.get('traverse_child', False)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 51 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 52 |  |  | # -- Base Class ---------------------------------------------------------------- | 
            
                                                                                                            
                            
            
                                    
            
            
                | 53 |  |  | class EdgesBase(object): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 54 |  |  |     """Base class for GoEdges class.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 55 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 56 |  |  |     def __init__(self, gosubdag): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 57 |  |  |         self.gosubdag = gosubdag | 
            
                                                                                                            
                            
            
                                    
            
            
                | 58 |  |  |         self.go2obj = gosubdag.go2obj | 
            
                                                                                                            
                            
            
                                    
            
            
                | 59 |  |  |         self.relationships = gosubdag.relationships | 
            
                                                                                                            
                            
            
                                    
            
            
                | 60 |  |  |         # Set by derived edge class | 
            
                                                                                                            
                            
            
                                    
            
            
                | 61 |  |  |         self.edges = []  # Lists of (goid_child, goid_parent) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 62 |  |  |         self.edges_rel = {} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 63 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 64 |  |  |     def rm_gos(self, rm_goids): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 65 |  |  |         """Remove any edges that contain user-specified edges.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 66 |  |  |         self.edges = self._rm_gos_edges(rm_goids, self.edges) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 67 |  |  |         self.edges_rel = self._rm_gos_edges_rel(rm_goids, self.edges_rel) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 68 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 69 |  |  |     def _rm_gos_edges_rel(self, rm_goids, edges_rel): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 70 |  |  |         """Remove any relationship that contain user-specified edges.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 71 |  |  |         edges_ret = {} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 72 |  |  |         for rname, edges_cur in edges_rel.items(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 73 |  |  |             edges_new = self._rm_gos_edges(rm_goids, edges_cur) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 74 |  |  |             if edges_new: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 75 |  |  |                 edges_ret[rname] = edges_new | 
            
                                                                                                            
                            
            
                                    
            
            
                | 76 |  |  |         return edges_ret | 
            
                                                                                                            
                            
            
                                    
            
            
                | 77 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 78 |  |  |     @staticmethod | 
            
                                                                                                            
                            
            
                                    
            
            
                | 79 |  |  |     def _rm_gos_edges(rm_goids, edges_all): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 80 |  |  |         """Remove any is_a edges that contain user-specified edges.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 81 |  |  |         edges_reduced = [] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 82 |  |  |         for goid_child, goid_parent in sorted(edges_all, key=lambda t: t[1]): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 83 |  |  |             if goid_child not in rm_goids and goid_parent not in rm_goids: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 84 |  |  |                 edges_reduced.append((goid_child, goid_parent)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 85 |  |  |         return edges_reduced | 
            
                                                                                                            
                            
            
                                    
            
            
                | 86 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 87 |  |  |     def get_all_edge_nodes(self): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 88 |  |  |         """Return a list of all GO IDs that are connected to edges.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 89 |  |  |         edge_nodes = set(e for es in self.edges for e in es) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 90 |  |  |         for edges in self.edges_rel.values(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 91 |  |  |             rel_nodes = set(e for es in edges for e in es) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 92 |  |  |             edge_nodes.update(rel_nodes) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 93 |  |  |         return edge_nodes | 
            
                                                                                                            
                                                                
            
                                    
            
            
                | 94 |  |  |  | 
            
                                                                        
                            
            
                                    
            
            
                | 95 |  |  |     def chk_edges(self): | 
            
                                                                        
                            
            
                                    
            
            
                | 96 |  |  |         """Check that all edge nodes exist in local subset.""" | 
            
                                                                        
                            
            
                                    
            
            
                | 97 |  |  |         goids = set(self.go2obj) | 
            
                                                                        
                            
            
                                    
            
            
                | 98 |  |  |         self.chk_edges_nodes(self.edges, goids, "is_a") | 
            
                                                                        
                            
            
                                    
            
            
                | 99 |  |  |         for reltype, edges in self.edges_rel.items(): | 
            
                                                                        
                            
            
                                    
            
            
                | 100 |  |  |             self.chk_edges_nodes(edges, goids, reltype) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 101 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 102 |  |  |     @staticmethod | 
            
                                                                                                            
                            
            
                                    
            
            
                | 103 |  |  |     def chk_edges_nodes(edges, nodes, name): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 104 |  |  |         """Check that user specified edges have a node which exists.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 105 |  |  |         edge_nodes = set(e for es in edges for e in es) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 106 |  |  |         missing_nodes = edge_nodes.difference(nodes) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 107 |  |  |         assert not missing_nodes, "MISSING: {GOs}\n{NM} EDGES MISSING {N} NODES (OF {T})".format( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 108 |  |  |             NM=name, N=len(missing_nodes), T=len(edge_nodes), GOs=missing_nodes) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 109 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 110 |  |  |     def get_c2ps(self): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 111 |  |  |         """Set child2parents dict for all parents used in this set of edges.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 112 |  |  |         c2ps = defaultdict(set) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 113 |  |  |         for goid_child, goid_parent in self.edges: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 114 |  |  |             c2ps[goid_child].add(goid_parent) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 115 |  |  |         return c2ps | 
            
                                                                                                            
                            
            
                                    
            
            
                | 116 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 117 |  |  |     def _getobjs_higher(self, goobj): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 118 |  |  |         """Get all parents/relationships on this GOTerm.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 119 |  |  |         goobjs_higher = set(goobj.parents) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 120 |  |  |         for reltyp, relgoobjs in goobj.relationship.items(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 121 |  |  |             if reltyp in self.relationships: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 122 |  |  |                 goobjs_higher.update(relgoobjs) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 123 |  |  |         return goobjs_higher | 
            
                                                                                                            
                            
            
                                    
            
            
                | 124 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 125 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 126 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 127 |  |  | # -- Initialization by considering all child and/or parent relatives ----------- | 
            
                                                                                                            
                            
            
                                    
            
            
                | 128 |  |  | class EdgesRelatives(EdgesBase): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 129 |  |  |     """Inits GO-to-GO edges using all relatives above and/or below source GOs.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 130 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 131 |  |  |     # pylint: disable=too-many-arguments | 
            
                                                                                                            
                            
            
                                    
            
            
                | 132 |  |  |     # def __init__(self, go2obj, relationships, go_sources, traverse_parent, traverse_child): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 133 |  |  |     def __init__(self, gosubdag, traverse_parent, traverse_child): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 134 |  |  |         super(EdgesRelatives, self).__init__(gosubdag) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 135 |  |  |         # go2obj contain GO IDs in subset | 
            
                                                                                                            
                            
            
                                    
            
            
                | 136 |  |  |         _gos = set(gosubdag.go2obj) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 137 |  |  |         assert traverse_child or traverse_parent, "NO EDGES IN GRAPH" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 138 |  |  |         # GO IDs for child->parents | 
            
                                                                                                            
                            
            
                                    
            
            
                | 139 |  |  |         p2cs = self._init_p2cs(_gos, traverse_parent) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 140 |  |  |         # GO IDs for parent->children | 
            
                                                                                                            
                            
            
                                    
            
            
                | 141 |  |  |         c2ps = self._init_c2ps(gosubdag.go_sources, traverse_child) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 142 |  |  |         # GO IDs for GO->relationship | 
            
                                                                                                            
                            
            
                                    
            
            
                | 143 |  |  |         rel2src2dsts = self._init_rel2src2dsts(_gos, traverse_parent) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 144 |  |  |         rel2dst2srcs = self._init_rel2dst2srcs(_gos, traverse_child) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 145 |  |  |         # Set by derived edge class | 
            
                                                                                                            
                            
            
                                    
            
            
                | 146 |  |  |         # self.edges = self._init_edges(_gos, p2cs, c2ps) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 147 |  |  |         self.edges = self._init_edges(p2cs, c2ps) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 148 |  |  |         self.edges_rel = self._init_edges_relationships(rel2src2dsts, rel2dst2srcs) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 149 |  |  |         assert _gos == set(self.go2obj) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 150 |  |  |         # self.chk_edges() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 151 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 152 |  |  |     @staticmethod | 
            
                                                                                                            
                            
            
                                    
            
            
                | 153 |  |  |     # Too slow to check goids_present as we go. Only minor init modes need checking. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 154 |  |  |     # def _init_edges(goids_present, p2cs, c2ps): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 155 |  |  |     def _init_edges(p2cs, c2ps): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 156 |  |  |         """Get the directed edges from GO term to GO term.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 157 |  |  |         edge_from_to = [] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 158 |  |  |         for parent, children in p2cs.items(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 159 |  |  |             for child in children: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 160 |  |  |                 # if child in goids_present and parent in goids_present: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 161 |  |  |                 edge_from_to.append((child, parent)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 162 |  |  |         for parent, children in c2ps.items(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 163 |  |  |             for child in children: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 164 |  |  |                 # if child in goids_present and parent in goids_present: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 165 |  |  |                 edge_from_to.append((child, parent)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 166 |  |  |         return edge_from_to | 
            
                                                                                                            
                            
            
                                    
            
            
                | 167 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 168 |  |  |     @staticmethod | 
            
                                                                                                            
                            
            
                                    
            
            
                | 169 |  |  |     def _init_edges_relationships(rel2src2dsts, rel2dst2srcs): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 170 |  |  |         """Get the directed edges from GO term to GO term using relationships.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 171 |  |  |         edge_rel2fromto = {} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 172 |  |  |         relationships = set(rel2src2dsts).union(rel2dst2srcs) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 173 |  |  |         for reltype in relationships: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 174 |  |  |             edge_from_to = [] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 175 |  |  |             if reltype in rel2src2dsts: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 176 |  |  |                 for parent, children in rel2src2dsts[reltype].items(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 177 |  |  |                     for child in children: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 178 |  |  |                         edge_from_to.append((child, parent)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 179 |  |  |             if reltype in rel2dst2srcs: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 180 |  |  |                 for parent, children in rel2dst2srcs[reltype].items(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 181 |  |  |                     for child in children: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 182 |  |  |                         edge_from_to.append((child, parent)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 183 |  |  |             edge_rel2fromto[reltype] = edge_from_to | 
            
                                                                                                            
                            
            
                                    
            
            
                | 184 |  |  |         return edge_rel2fromto | 
            
                                                                                                            
                            
            
                                    
            
            
                | 185 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 186 |  |  |     # ------------------------------------------------------------------- | 
            
                                                                                                            
                            
            
                                    
            
            
                | 187 |  |  |     def _init_rel2src2dsts(self, go_sources, traverse_parent): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 188 |  |  |         """Traverse up parents.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 189 |  |  |         if not traverse_parent or not self.relationships: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 190 |  |  |             return {} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 191 |  |  |         rel2src2dsts = {r:defaultdict(set) for r in self.relationships} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 192 |  |  |         goids_seen = set() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 193 |  |  |         go2obj = self.go2obj | 
            
                                                                                                            
                            
            
                                    
            
            
                | 194 |  |  |         for goid_src in go_sources: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 195 |  |  |             goobj_src = go2obj[goid_src] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 196 |  |  |             if goobj_src.relationship and goid_src not in goids_seen: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 197 |  |  |                 self._traverse_relationship_objs(rel2src2dsts, goobj_src, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 198 |  |  |         return rel2src2dsts | 
            
                                                                                                            
                            
            
                                    
            
            
                | 199 |  |  |  | 
            
                                                                                                            
                            
            
                                                                    
                                                                                                        
            
            
                | 200 |  | View Code Duplication |     def _traverse_relationship_objs(self, rel2src2dsts, goobj_child, goids_seen): | 
                            
                    |  |  |  | 
                                                                                        
                                                                                     | 
            
                                                                                                            
                            
            
                                    
            
            
                | 201 |  |  |         """Traverse from source GO up relationships.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 202 |  |  |         child_id = goobj_child.id | 
            
                                                                                                            
                            
            
                                    
            
            
                | 203 |  |  |         goids_seen.add(child_id) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 204 |  |  |         ##A self.go2obj[child_id] = goobj_child | 
            
                                                                                                            
                            
            
                                    
            
            
                | 205 |  |  |         # Update goids_seen and go2obj with child alt_ids | 
            
                                                                                                            
                            
            
                                    
            
            
                | 206 |  |  |         for goid_altid in goobj_child.alt_ids: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 207 |  |  |             goids_seen.add(goid_altid) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 208 |  |  |             ##A self.go2obj[goid_altid] = goobj_child | 
            
                                                                                                            
                            
            
                                    
            
            
                | 209 |  |  |         # Loop through relationships of child object | 
            
                                                                                                            
                            
            
                                    
            
            
                | 210 |  |  |         for reltype, recs in goobj_child.relationship.items(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 211 |  |  |             if reltype in self.relationships: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 212 |  |  |                 for relationship_obj in recs: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 213 |  |  |                     relationship_id = relationship_obj.id | 
            
                                                                                                            
                            
            
                                    
            
            
                | 214 |  |  |                     rel2src2dsts[reltype][relationship_id].add(child_id) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 215 |  |  |                     # If relationship has not been seen, traverse | 
            
                                                                                                            
                            
            
                                    
            
            
                | 216 |  |  |                     if relationship_id not in goids_seen: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 217 |  |  |                         self._traverse_relationship_objs(rel2src2dsts, relationship_obj, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 218 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 219 |  |  |     # ------------------------------------------------------------------- | 
            
                                                                                                            
                            
            
                                    
            
            
                | 220 |  |  |     def _init_rel2dst2srcs(self, go_sources, traverse_child): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 221 |  |  |         """Traverse through reverse relationships.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 222 |  |  |         if not traverse_child or not self.relationships: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 223 |  |  |             return {} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 224 |  |  |         rel2dst2srcs = {r:defaultdict(set) for r in self.relationships} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 225 |  |  |         goids_seen = set() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 226 |  |  |         go2obj = self.go2obj | 
            
                                                                                                            
                            
            
                                    
            
            
                | 227 |  |  |         for goid_src in go_sources: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 228 |  |  |             goobj_src = go2obj[goid_src] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 229 |  |  |             if goid_src not in goids_seen: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 230 |  |  |                 self._traverse_relationship_rev_objs(rel2dst2srcs, goobj_src, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 231 |  |  |         return rel2dst2srcs | 
            
                                                                                                            
                            
            
                                    
            
            
                | 232 |  |  |  | 
            
                                                                                                            
                            
            
                                                                    
                                                                                                        
            
            
                | 233 |  | View Code Duplication |     def _traverse_relationship_rev_objs(self, rel2dst2srcs, goobj_parent, goids_seen): | 
                            
                    |  |  |  | 
                                                                                        
                                                                                     | 
            
                                                                                                            
                            
            
                                    
            
            
                | 234 |  |  |         """Traverse from source GO down children.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 235 |  |  |         parent_id = goobj_parent.id | 
            
                                                                                                            
                            
            
                                    
            
            
                | 236 |  |  |         goids_seen.add(parent_id) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 237 |  |  |         ##A self.go2obj[parent_id] = goobj_parent | 
            
                                                                                                            
                            
            
                                    
            
            
                | 238 |  |  |         # Update goids_seen and go2obj with parent alt_ids | 
            
                                                                                                            
                            
            
                                    
            
            
                | 239 |  |  |         for goid_altid in goobj_parent.alt_ids: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 240 |  |  |             goids_seen.add(goid_altid) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 241 |  |  |             ##A self.go2obj[goid_altid] = goobj_parent | 
            
                                                                                                            
                            
            
                                    
            
            
                | 242 |  |  |         # Loop through children | 
            
                                                                                                            
                            
            
                                    
            
            
                | 243 |  |  |         for reltype, recs in goobj_parent.relationship.items(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 244 |  |  |             if reltype in self.relationships: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 245 |  |  |                 for relrev_obj in recs: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 246 |  |  |                     relrev_id = relrev_obj.id | 
            
                                                                                                            
                            
            
                                    
            
            
                | 247 |  |  |                     rel2dst2srcs[relrev_id].add(parent_id) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 248 |  |  |                     # If child has not been seen, traverse | 
            
                                                                                                            
                            
            
                                    
            
            
                | 249 |  |  |                     if relrev_id not in goids_seen: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 250 |  |  |                         ##F self._traverse_relrev_objs(rel2dst2srcs, relrev_obj, go2obj, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 251 |  |  |                         self._traverse_relationship_rev_objs(rel2dst2srcs, relrev_obj, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 252 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 253 |  |  |     # ------------------------------------------------------------------- | 
            
                                                                                                            
                            
            
                                    
            
            
                | 254 |  |  |     def _init_p2cs(self, go_sources, traverse_parent): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 255 |  |  |         """Traverse up parents.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 256 |  |  |         if not traverse_parent: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 257 |  |  |             return {} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 258 |  |  |         p2cs = defaultdict(set) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 259 |  |  |         goids_seen = set() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 260 |  |  |         go2obj = self.go2obj | 
            
                                                                                                            
                            
            
                                    
            
            
                | 261 |  |  |         for goid_src in go_sources: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 262 |  |  |             goobj_src = go2obj[goid_src] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 263 |  |  |             if goid_src not in goids_seen: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 264 |  |  |                 ##F self._traverse_parent_objs(p2cs, goobj_src, go2obj, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 265 |  |  |                 self._traverse_parent_objs(p2cs, goobj_src, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 266 |  |  |         return p2cs | 
            
                                                                                                            
                            
            
                                    
            
            
                | 267 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 268 |  |  |     ##F def _traverse_parent_objs(self, p2cs, goobj_child, go2obj, goids_seen): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 269 |  |  |     def _traverse_parent_objs(self, p2cs, goobj_child, goids_seen): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 270 |  |  |         """Traverse from source GO up parents.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 271 |  |  |         # Update public(go2obj p2cs), private(goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 272 |  |  |         child_id = goobj_child.id | 
            
                                                                                                            
                            
            
                                    
            
            
                | 273 |  |  |         # mark child as seen | 
            
                                                                                                            
                            
            
                                    
            
            
                | 274 |  |  |         goids_seen.add(child_id) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 275 |  |  |         ##A self.go2obj[child_id] = goobj_child | 
            
                                                                                                            
                            
            
                                    
            
            
                | 276 |  |  |         # Update goids_seen and go2obj with child alt_ids | 
            
                                                                                                            
                            
            
                                    
            
            
                | 277 |  |  |         for goid_altid in goobj_child.alt_ids: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 278 |  |  |             goids_seen.add(goid_altid) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 279 |  |  |             ##A self.go2obj[goid_altid] = goobj_child | 
            
                                                                                                            
                            
            
                                    
            
            
                | 280 |  |  |         # Loop through parents of child object | 
            
                                                                                                            
                            
            
                                    
            
            
                | 281 |  |  |         for parent_obj in goobj_child.parents: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 282 |  |  |             parent_id = parent_obj.id | 
            
                                                                                                            
                            
            
                                    
            
            
                | 283 |  |  |             p2cs[parent_id].add(child_id) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 284 |  |  |             # If parent has not been seen, traverse | 
            
                                                                                                            
                            
            
                                    
            
            
                | 285 |  |  |             if parent_id not in goids_seen: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 286 |  |  |                 ##F self._traverse_parent_objs(p2cs, parent_obj, go2obj, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 287 |  |  |                 self._traverse_parent_objs(p2cs, parent_obj, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 288 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 289 |  |  |     # ------------------------------------------------------------------- | 
            
                                                                                                            
                            
            
                                    
            
            
                | 290 |  |  |     def _init_c2ps(self, go_sources, traverse_child): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 291 |  |  |         """Traverse up children.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 292 |  |  |         if not traverse_child: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 293 |  |  |             return {} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 294 |  |  |         c2ps = defaultdict(set) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 295 |  |  |         goids_seen = set() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 296 |  |  |         go2obj = self.go2obj | 
            
                                                                                                            
                            
            
                                    
            
            
                | 297 |  |  |         for goid_src in go_sources: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 298 |  |  |             goobj_src = go2obj[goid_src] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 299 |  |  |             if goid_src not in goids_seen: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 300 |  |  |                 ##F self._traverse_child_objs(c2ps, goobj_src, go2obj, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 301 |  |  |                 self._traverse_child_objs(c2ps, goobj_src, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 302 |  |  |         return c2ps | 
            
                                                                                                            
                            
            
                                    
            
            
                | 303 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 304 |  |  |     ##F def _traverse_child_objs(self, c2ps, goobj_parent, go2obj, goids_seen): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 305 |  |  |     def _traverse_child_objs(self, c2ps, goobj_parent, goids_seen): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 306 |  |  |         """Traverse from source GO down children.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 307 |  |  |         # Update public(godag.go2obj godag.c2ps), private(_seen_pids) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 308 |  |  |         parent_id = goobj_parent.id | 
            
                                                                                                            
                            
            
                                    
            
            
                | 309 |  |  |         # mark parent as seen | 
            
                                                                                                            
                            
            
                                    
            
            
                | 310 |  |  |         goids_seen.add(parent_id) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 311 |  |  |         ##A self.go2obj[parent_id] = goobj_parent | 
            
                                                                                                            
                            
            
                                    
            
            
                | 312 |  |  |         # Update goids_seen and go2obj with parent alt_ids | 
            
                                                                                                            
                            
            
                                    
            
            
                | 313 |  |  |         for goid_altid in goobj_parent.alt_ids: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 314 |  |  |             goids_seen.add(goid_altid) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 315 |  |  |             ##A self.go2obj[goid_altid] = goobj_parent | 
            
                                                                                                            
                            
            
                                    
            
            
                | 316 |  |  |         # Loop through children | 
            
                                                                                                            
                            
            
                                    
            
            
                | 317 |  |  |         for child_obj in goobj_parent.children: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 318 |  |  |             child_id = child_obj.id | 
            
                                                                                                            
                            
            
                                    
            
            
                | 319 |  |  |             c2ps[child_id].add(parent_id) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 320 |  |  |             # If child has not been seen, traverse | 
            
                                                                                                            
                            
            
                                    
            
            
                | 321 |  |  |             if child_id not in goids_seen: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 322 |  |  |                 ##F self._traverse_child_objs(c2ps, child_obj, go2obj, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 323 |  |  |                 self._traverse_child_objs(c2ps, child_obj, goids_seen) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 324 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 325 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 326 |  |  | # -- Initialization with realtives on specific src-dst paths ------------------- | 
            
                                                                                                            
                            
            
                                    
            
            
                | 327 |  |  | class EdgesPath(EdgesBase): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 328 |  |  |     """Inits GO-to-GO edges using a list of (parent destination, child sources)""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 329 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 330 |  |  |     def __init__(self, gosubdag, dst_srcs_list): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 331 |  |  |         super(EdgesPath, self).__init__(gosubdag) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 332 |  |  |         self.edges = None | 
            
                                                                                                            
                            
            
                                    
            
            
                | 333 |  |  |         self.goid_all = None | 
            
                                                                                                            
                            
            
                                    
            
            
                | 334 |  |  |         self._init_edges(dst_srcs_list) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 335 |  |  |         # GO IDs for child->parents | 
            
                                                                                                            
                            
            
                                    
            
            
                | 336 |  |  |         # self.p2cs = self._init_p2cs(go_sources, traverse_parent) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 337 |  |  |         # GO IDs for parent->children | 
            
                                                                                                            
                            
            
                                    
            
            
                | 338 |  |  |         # self.c2ps = self._init_c2ps(go_sources, traverse_child) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 339 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 340 |  |  |     def get_edges(self): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 341 |  |  |         """Get the directed edges from GO term to GO term.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 342 |  |  |         return self.edges | 
            
                                                                                                            
                            
            
                                    
            
            
                | 343 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 344 |  |  |     def _init_edges(self, dst_srcs_list): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 345 |  |  |         """Create all GO edges given a list of (dst, srcs).""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 346 |  |  |         from goatools.gosubdag.go_paths import get_paths_goobjs, paths2edges | 
            
                                                                                                            
                            
            
                                    
            
            
                | 347 |  |  |         edges_all = set() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 348 |  |  |         goid_all = set() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 349 |  |  |         go2obj = self.go2obj | 
            
                                                                                                            
                            
            
                                    
            
            
                | 350 |  |  |         for dst, srcs in dst_srcs_list: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 351 |  |  |             go2obj_srcs = {} | 
            
                                                                                                            
                            
            
                                    
            
            
                | 352 |  |  |             for goid in srcs: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 353 |  |  |                 go2obj_srcs[goid] = go2obj[goid] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 354 |  |  |             go_paths, go_all = get_paths_goobjs(go2obj_srcs.values(), go_top=dst, go2obj=go2obj) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 355 |  |  |             edges_all |= paths2edges(go_paths) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 356 |  |  |             goid_all |= go_all | 
            
                                                                                                            
                            
            
                                    
            
            
                | 357 |  |  |         self.edges = [(a.id, b.id) for a, b in edges_all] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 358 |  |  |         self.goid_all = goid_all | 
            
                                                                                                            
                            
            
                                    
            
            
                | 359 |  |  |  | 
            
                                                                                                            
                                                                
            
                                    
            
            
                | 360 |  |  | # Copyright (C) 2016-2018, DV Klopfenstein, H Tang, All rights reserved. | 
            
                                                        
            
                                    
            
            
                | 361 |  |  |  |