| 1 |  |  | import warnings | 
            
                                                                                                            
                            
            
                                    
            
            
                | 2 |  |  | from pathlib import Path | 
            
                                                                                                            
                            
            
                                    
            
            
                | 3 |  |  | from typing import Any, Dict, Tuple, Optional, Union, Sequence, List | 
            
                                                                                                            
                            
            
                                    
            
            
                | 4 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 5 |  |  | import torch | 
            
                                                                                                            
                            
            
                                    
            
            
                | 6 |  |  | import humanize | 
            
                                                                                                            
                            
            
                                    
            
            
                | 7 |  |  | import numpy as np | 
            
                                                                                                            
                            
            
                                    
            
            
                | 8 |  |  | from PIL import Image as ImagePIL | 
            
                                                                                                            
                            
            
                                    
            
            
                | 9 |  |  | import nibabel as nib | 
            
                                                                                                            
                            
            
                                    
            
            
                | 10 |  |  | import SimpleITK as sitk | 
            
                                                                                                            
                            
            
                                    
            
            
                | 11 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 12 |  |  | from ..utils import get_stem | 
            
                                                                                                            
                            
            
                                    
            
            
                | 13 |  |  | from ..typing import TypeData, TypePath, TypeTripletInt, TypeTripletFloat | 
            
                                                                                                            
                            
            
                                    
            
            
                | 14 |  |  | from ..constants import DATA, TYPE, AFFINE, PATH, STEM, INTENSITY, LABEL | 
            
                                                                                                            
                            
            
                                    
            
            
                | 15 |  |  | from .io import ( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 16 |  |  |     ensure_4d, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 17 |  |  |     read_image, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 18 |  |  |     write_image, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 19 |  |  |     nib_to_sitk, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 20 |  |  |     check_uint_to_int, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 21 |  |  |     get_rotation_and_spacing_from_affine, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 22 |  |  | ) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 23 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 24 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 25 |  |  | PROTECTED_KEYS = DATA, AFFINE, TYPE, PATH, STEM | 
            
                                                                                                            
                            
            
                                    
            
            
                | 26 |  |  | TypeBound = Tuple[float, float] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 27 |  |  | TypeBounds = Tuple[TypeBound, TypeBound, TypeBound] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 28 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 29 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 30 |  |  | class Image(dict): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 31 |  |  |     r"""TorchIO image. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 32 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 33 |  |  |     For information about medical image orientation, check out `NiBabel docs`_, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 34 |  |  |     the `3D Slicer wiki`_, `Graham Wideman's website`_, `FSL docs`_ or | 
            
                                                                                                            
                            
            
                                    
            
            
                | 35 |  |  |     `SimpleITK docs`_. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 36 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 37 |  |  |     Args: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 38 |  |  |         path: Path to a file or sequence of paths to files that can be read by | 
            
                                                                                                            
                            
            
                                    
            
            
                | 39 |  |  |             :mod:`SimpleITK` or :mod:`nibabel`, or to a directory containing | 
            
                                                                                                            
                            
            
                                    
            
            
                | 40 |  |  |             DICOM files. If :attr:`tensor` is given, the data in | 
            
                                                                                                            
                            
            
                                    
            
            
                | 41 |  |  |             :attr:`path` will not be read. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 42 |  |  |             If a sequence of paths is given, data | 
            
                                                                                                            
                            
            
                                    
            
            
                | 43 |  |  |             will be concatenated on the channel dimension so spatial | 
            
                                                                                                            
                            
            
                                    
            
            
                | 44 |  |  |             dimensions must match. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 45 |  |  |         type: Type of image, such as :attr:`torchio.INTENSITY` or | 
            
                                                                                                            
                            
            
                                    
            
            
                | 46 |  |  |             :attr:`torchio.LABEL`. This will be used by the transforms to | 
            
                                                                                                            
                            
            
                                    
            
            
                | 47 |  |  |             decide whether to apply an operation, or which interpolation to use | 
            
                                                                                                            
                            
            
                                    
            
            
                | 48 |  |  |             when resampling. For example, `preprocessing`_ and `augmentation`_ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 49 |  |  |             intensity transforms will only be applied to images with type | 
            
                                                                                                            
                            
            
                                    
            
            
                | 50 |  |  |             :attr:`torchio.INTENSITY`. Spatial transforms will be applied to | 
            
                                                                                                            
                            
            
                                    
            
            
                | 51 |  |  |             all types, and nearest neighbor interpolation is always used to | 
            
                                                                                                            
                            
            
                                    
            
            
                | 52 |  |  |             resample images with type :attr:`torchio.LABEL`. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 53 |  |  |             The type :attr:`torchio.SAMPLING_MAP` may be used with instances of | 
            
                                                                                                            
                            
            
                                    
            
            
                | 54 |  |  |             :class:`~torchio.data.sampler.weighted.WeightedSampler`. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 55 |  |  |         tensor: If :attr:`path` is not given, :attr:`tensor` must be a 4D | 
            
                                                                                                            
                            
            
                                    
            
            
                | 56 |  |  |             :class:`torch.Tensor` or NumPy array with dimensions | 
            
                                                                                                            
                            
            
                                    
            
            
                | 57 |  |  |             :math:`(C, W, H, D)`. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 58 |  |  |         affine: If :attr:`path` is not given, :attr:`affine` must be a | 
            
                                                                                                            
                            
            
                                    
            
            
                | 59 |  |  |             :math:`4 \times 4` NumPy array. If ``None``, :attr:`affine` is an | 
            
                                                                                                            
                            
            
                                    
            
            
                | 60 |  |  |             identity matrix. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 61 |  |  |         check_nans: If ``True``, issues a warning if NaNs are found | 
            
                                                                                                            
                            
            
                                    
            
            
                | 62 |  |  |             in the image. If ``False``, images will not be checked for the | 
            
                                                                                                            
                            
            
                                    
            
            
                | 63 |  |  |             presence of NaNs. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 64 |  |  |         **kwargs: Items that will be added to the image dictionary, e.g. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 65 |  |  |             acquisition parameters. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 66 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 67 |  |  |     TorchIO images are `lazy loaders`_, i.e. the data is only loaded from disk | 
            
                                                                                                            
                            
            
                                    
            
            
                | 68 |  |  |     when needed. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 69 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 70 |  |  |     Example: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 71 |  |  |         >>> import torchio as tio | 
            
                                                                                                            
                            
            
                                    
            
            
                | 72 |  |  |         >>> image = tio.ScalarImage('t1.nii.gz')  # subclass of Image | 
            
                                                                                                            
                            
            
                                    
            
            
                | 73 |  |  |         >>> image  # not loaded yet | 
            
                                                                                                            
                            
            
                                    
            
            
                | 74 |  |  |         ScalarImage(path: t1.nii.gz; type: intensity) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 75 |  |  |         >>> times_two = 2 * image.data  # data is loaded and cached here | 
            
                                                                                                            
                            
            
                                    
            
            
                | 76 |  |  |         >>> image | 
            
                                                                                                            
                            
            
                                    
            
            
                | 77 |  |  |         ScalarImage(shape: (1, 256, 256, 176); spacing: (1.00, 1.00, 1.00); orientation: PIR+; memory: 44.0 MiB; type: intensity) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 78 |  |  |         >>> image.save('doubled_image.nii.gz') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 79 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 80 |  |  |     .. _lazy loaders: https://en.wikipedia.org/wiki/Lazy_loading | 
            
                                                                                                            
                            
            
                                    
            
            
                | 81 |  |  |     .. _preprocessing: https://torchio.readthedocs.io/transforms/preprocessing.html#intensity | 
            
                                                                                                            
                            
            
                                    
            
            
                | 82 |  |  |     .. _augmentation: https://torchio.readthedocs.io/transforms/augmentation.html#intensity | 
            
                                                                                                            
                            
            
                                    
            
            
                | 83 |  |  |     .. _NiBabel docs: https://nipy.org/nibabel/image_orientation.html | 
            
                                                                                                            
                            
            
                                    
            
            
                | 84 |  |  |     .. _3D Slicer wiki: https://www.slicer.org/wiki/Coordinate_systems | 
            
                                                                                                            
                            
            
                                    
            
            
                | 85 |  |  |     .. _FSL docs: https://fsl.fmrib.ox.ac.uk/fsl/fslwiki/Orientation%20Explained | 
            
                                                                                                            
                            
            
                                    
            
            
                | 86 |  |  |     .. _SimpleITK docs: https://simpleitk.readthedocs.io/en/master/fundamentalConcepts.html | 
            
                                                                                                            
                            
            
                                    
            
            
                | 87 |  |  |     .. _Graham Wideman's website: http://www.grahamwideman.com/gw/brain/orientation/orientterms.htm | 
            
                                                                                                            
                            
            
                                    
            
            
                | 88 |  |  |     """ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 89 |  |  |     def __init__( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 90 |  |  |             self, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 91 |  |  |             path: Union[TypePath, Sequence[TypePath], None] = None, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 92 |  |  |             type: str = None, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 93 |  |  |             tensor: Optional[TypeData] = None, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 94 |  |  |             affine: Optional[TypeData] = None, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 95 |  |  |             check_nans: bool = False,  # removed by ITK by default | 
            
                                                                                                            
                            
            
                                    
            
            
                | 96 |  |  |             channels_last: bool = False, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 97 |  |  |             **kwargs: Dict[str, Any], | 
            
                                                                                                            
                            
            
                                    
            
            
                | 98 |  |  |             ): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 99 |  |  |         self.check_nans = check_nans | 
            
                                                                                                            
                            
            
                                    
            
            
                | 100 |  |  |         self.channels_last = channels_last | 
            
                                                                                                            
                            
            
                                    
            
            
                | 101 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 102 |  |  |         if type is None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 103 |  |  |             warnings.warn( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 104 |  |  |                 'Not specifying the image type is deprecated and will be' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 105 |  |  |                 ' mandatory in the future. You can probably use tio.ScalarImage' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 106 |  |  |                 'or LabelMap instead', DeprecationWarning, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 107 |  |  |             ) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 108 |  |  |             type = INTENSITY | 
            
                                                                                                            
                            
            
                                    
            
            
                | 109 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 110 |  |  |         if path is None and tensor is None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 111 |  |  |             raise ValueError('A value for path or tensor must be given') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 112 |  |  |         self._loaded = False | 
            
                                                                                                            
                            
            
                                    
            
            
                | 113 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 114 |  |  |         tensor = self._parse_tensor(tensor) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 115 |  |  |         affine = self._parse_affine(affine) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 116 |  |  |         if tensor is not None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 117 |  |  |             self.data = tensor | 
            
                                                                                                            
                            
            
                                    
            
            
                | 118 |  |  |             self.affine = affine | 
            
                                                                                                            
                            
            
                                    
            
            
                | 119 |  |  |             self._loaded = True | 
            
                                                                                                            
                            
            
                                    
            
            
                | 120 |  |  |         for key in PROTECTED_KEYS: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 121 |  |  |             if key in kwargs: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 122 |  |  |                 message = f'Key "{key}" is reserved. Use a different one' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 123 |  |  |                 raise ValueError(message) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 124 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 125 |  |  |         super().__init__(**kwargs) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 126 |  |  |         self.path = self._parse_path(path) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 127 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 128 |  |  |         self[PATH] = '' if self.path is None else str(self.path) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 129 |  |  |         self[STEM] = '' if self.path is None else get_stem(self.path) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 130 |  |  |         self[TYPE] = type | 
            
                                                                                                            
                            
            
                                    
            
            
                | 131 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 132 |  |  |     def __repr__(self): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 133 |  |  |         properties = [] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 134 |  |  |         if self._loaded: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 135 |  |  |             properties.extend([ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 136 |  |  |                 f'shape: {self.shape}', | 
            
                                                                                                            
                            
            
                                    
            
            
                | 137 |  |  |                 f'spacing: {self.get_spacing_string()}', | 
            
                                                                                                            
                            
            
                                    
            
            
                | 138 |  |  |                 f'orientation: {"".join(self.orientation)}+', | 
            
                                                                                                            
                            
            
                                    
            
            
                | 139 |  |  |                 f'memory: {humanize.naturalsize(self.memory, binary=True)}', | 
            
                                                                                                            
                            
            
                                    
            
            
                | 140 |  |  |             ]) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 141 |  |  |         else: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 142 |  |  |             properties.append(f'path: "{self.path}"') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 143 |  |  |         if self._loaded: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 144 |  |  |             properties.append(f'dtype: {self.data.type()}') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 145 |  |  |         properties = '; '.join(properties) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 146 |  |  |         string = f'{self.__class__.__name__}({properties})' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 147 |  |  |         return string | 
            
                                                                                                            
                            
            
                                    
            
            
                | 148 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 149 |  |  |     def __getitem__(self, item): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 150 |  |  |         if item in (DATA, AFFINE): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 151 |  |  |             if item not in self: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 152 |  |  |                 self.load() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 153 |  |  |         return super().__getitem__(item) | 
            
                                                                                                            
                                                                
            
                                    
            
            
                | 154 |  |  |  | 
            
                                                                        
                            
            
                                    
            
            
                | 155 |  |  |     def __array__(self): | 
            
                                                                        
                            
            
                                    
            
            
                | 156 |  |  |         return self.data.numpy() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 157 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 158 |  |  |     def __copy__(self): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 159 |  |  |         kwargs = dict( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 160 |  |  |             tensor=self.data, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 161 |  |  |             affine=self.affine, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 162 |  |  |             type=self.type, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 163 |  |  |             path=self.path, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 164 |  |  |         ) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 165 |  |  |         for key, value in self.items(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 166 |  |  |             if key in PROTECTED_KEYS: continue | 
            
                                                                                                            
                            
            
                                    
            
            
                | 167 |  |  |             kwargs[key] = value  # should I copy? deepcopy? | 
            
                                                                                                            
                            
            
                                    
            
            
                | 168 |  |  |         return self.__class__(**kwargs) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 169 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 170 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 171 |  |  |     def data(self) -> torch.Tensor: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 172 |  |  |         """Tensor data. Same as :class:`Image.tensor`.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 173 |  |  |         return self[DATA] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 174 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 175 |  |  |     @data.setter | 
            
                                                                                                            
                            
            
                                    
            
            
                | 176 |  |  |     def data(self, tensor: TypeData): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 177 |  |  |         self[DATA] = self._parse_tensor(tensor, none_ok=False) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 178 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 179 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 180 |  |  |     def tensor(self) -> torch.Tensor: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 181 |  |  |         """Tensor data. Same as :class:`Image.data`.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 182 |  |  |         return self.data | 
            
                                                                                                            
                            
            
                                    
            
            
                | 183 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 184 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 185 |  |  |     def affine(self) -> np.ndarray: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 186 |  |  |         """Affine matrix to transform voxel indices into world coordinates.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 187 |  |  |         return self[AFFINE] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 188 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 189 |  |  |     @affine.setter | 
            
                                                                                                            
                            
            
                                    
            
            
                | 190 |  |  |     def affine(self, matrix): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 191 |  |  |         self[AFFINE] = self._parse_affine(matrix) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 192 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 193 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 194 |  |  |     def type(self) -> str: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 195 |  |  |         return self[TYPE] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 196 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 197 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 198 |  |  |     def shape(self) -> Tuple[int, int, int, int]: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 199 |  |  |         """Tensor shape as :math:`(C, W, H, D)`.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 200 |  |  |         return tuple(self.data.shape) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 201 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 202 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 203 |  |  |     def spatial_shape(self) -> TypeTripletInt: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 204 |  |  |         """Tensor spatial shape as :math:`(W, H, D)`.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 205 |  |  |         return self.shape[1:] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 206 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 207 |  |  |     def check_is_2d(self) -> None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 208 |  |  |         if not self.is_2d(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 209 |  |  |             message = f'Image is not 2D. Spatial shape: {self.spatial_shape}' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 210 |  |  |             raise RuntimeError(message) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 211 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 212 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 213 |  |  |     def height(self) -> int: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 214 |  |  |         """Image height, if 2D.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 215 |  |  |         self.check_is_2d() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 216 |  |  |         return self.spatial_shape[1] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 217 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 218 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 219 |  |  |     def width(self) -> int: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 220 |  |  |         """Image width, if 2D.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 221 |  |  |         self.check_is_2d() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 222 |  |  |         return self.spatial_shape[0] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 223 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 224 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 225 |  |  |     def orientation(self) -> Tuple[str, str, str]: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 226 |  |  |         """Orientation codes.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 227 |  |  |         return nib.aff2axcodes(self.affine) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 228 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 229 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 230 |  |  |     def spacing(self) -> Tuple[float, float, float]: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 231 |  |  |         """Voxel spacing in mm.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 232 |  |  |         _, spacing = get_rotation_and_spacing_from_affine(self.affine) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 233 |  |  |         return tuple(spacing) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 234 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 235 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 236 |  |  |     def memory(self) -> float: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 237 |  |  |         """Number of Bytes that the tensor takes in the RAM.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 238 |  |  |         return np.prod(self.shape) * 4  # float32, i.e. 4 bytes per voxel | 
            
                                                                                                            
                            
            
                                    
            
            
                | 239 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 240 |  |  |     @property | 
            
                                                                                                            
                            
            
                                    
            
            
                | 241 |  |  |     def bounds(self) -> np.ndarray: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 242 |  |  |         """Position of centers of voxels in smallest and largest coordinates.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 243 |  |  |         ini = 0, 0, 0 | 
            
                                                                                                            
                            
            
                                    
            
            
                | 244 |  |  |         fin = np.array(self.spatial_shape) - 1 | 
            
                                                                                                            
                            
            
                                    
            
            
                | 245 |  |  |         point_ini = nib.affines.apply_affine(self.affine, ini) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 246 |  |  |         point_fin = nib.affines.apply_affine(self.affine, fin) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 247 |  |  |         return np.array((point_ini, point_fin)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 248 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 249 |  |  |     def axis_name_to_index(self, axis: str) -> int: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 250 |  |  |         """Convert an axis name to an axis index. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 251 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 252 |  |  |         Args: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 253 |  |  |             axis: Possible inputs are ``'Left'``, ``'Right'``, ``'Anterior'``, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 254 |  |  |                 ``'Posterior'``, ``'Inferior'``, ``'Superior'``. Lower-case | 
            
                                                                                                            
                            
            
                                    
            
            
                | 255 |  |  |                 versions and first letters are also valid, as only the first | 
            
                                                                                                            
                            
            
                                    
            
            
                | 256 |  |  |                 letter will be used. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 257 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 258 |  |  |         .. note:: If you are working with animals, you should probably use | 
            
                                                                                                            
                            
            
                                    
            
            
                | 259 |  |  |             ``'Superior'``, ``'Inferior'``, ``'Anterior'`` and ``'Posterior'`` | 
            
                                                                                                            
                            
            
                                    
            
            
                | 260 |  |  |             for ``'Dorsal'``, ``'Ventral'``, ``'Rostral'`` and ``'Caudal'``, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 261 |  |  |             respectively. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 262 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 263 |  |  |         .. note:: If your images are 2D, you can use ``'Top'``, ``'Bottom'``, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 264 |  |  |             ``'Left'`` and ``'Right'``. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 265 |  |  |         """ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 266 |  |  |         # Top and bottom are used for the vertical 2D axis as the use of | 
            
                                                                                                            
                            
            
                                    
            
            
                | 267 |  |  |         # Height vs Horizontal might be ambiguous | 
            
                                                                                                            
                            
            
                                    
            
            
                | 268 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 269 |  |  |         if not isinstance(axis, str): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 270 |  |  |             raise ValueError('Axis must be a string') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 271 |  |  |         axis = axis[0].upper() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 272 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 273 |  |  |         # Generally, TorchIO tensors are (C, W, H, D) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 274 |  |  |         if axis in 'TB':  # Top, Bottom | 
            
                                                                                                            
                            
            
                                    
            
            
                | 275 |  |  |             return -2 | 
            
                                                                                                            
                            
            
                                    
            
            
                | 276 |  |  |         else: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 277 |  |  |             try: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 278 |  |  |                 index = self.orientation.index(axis) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 279 |  |  |             except ValueError: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 280 |  |  |                 index = self.orientation.index(self.flip_axis(axis)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 281 |  |  |             # Return negative indices so that it does not matter whether we | 
            
                                                                                                            
                            
            
                                    
            
            
                | 282 |  |  |             # refer to spatial dimensions or not | 
            
                                                                                                            
                            
            
                                    
            
            
                | 283 |  |  |             index = -3 + index | 
            
                                                                                                            
                            
            
                                    
            
            
                | 284 |  |  |             return index | 
            
                                                                                                            
                            
            
                                    
            
            
                | 285 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 286 |  |  |     # flake8: noqa: E701 | 
            
                                                                                                            
                            
            
                                    
            
            
                | 287 |  |  |     @staticmethod | 
            
                                                                                                            
                            
            
                                    
            
            
                | 288 |  |  |     def flip_axis(axis: str) -> str: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 289 |  |  |         if axis == 'R': flipped_axis = 'L' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 290 |  |  |         elif axis == 'L': flipped_axis = 'R' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 291 |  |  |         elif axis == 'A': flipped_axis = 'P' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 292 |  |  |         elif axis == 'P': flipped_axis = 'A' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 293 |  |  |         elif axis == 'I': flipped_axis = 'S' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 294 |  |  |         elif axis == 'S': flipped_axis = 'I' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 295 |  |  |         elif axis == 'T': flipped_axis = 'B' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 296 |  |  |         elif axis == 'B': flipped_axis = 'T' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 297 |  |  |         else: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 298 |  |  |             values = ', '.join('LRPAISTB') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 299 |  |  |             message = f'Axis not understood. Please use one of: {values}' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 300 |  |  |             raise ValueError(message) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 301 |  |  |         return flipped_axis | 
            
                                                                                                            
                            
            
                                    
            
            
                | 302 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 303 |  |  |     def get_spacing_string(self) -> str: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 304 |  |  |         strings = [f'{n:.2f}' for n in self.spacing] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 305 |  |  |         string = f'({", ".join(strings)})' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 306 |  |  |         return string | 
            
                                                                                                            
                            
            
                                    
            
            
                | 307 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 308 |  |  |     def get_bounds(self) -> TypeBounds: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 309 |  |  |         """Get minimum and maximum world coordinates occupied by the image.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 310 |  |  |         first_index = 3 * (-0.5,) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 311 |  |  |         last_index = np.array(self.spatial_shape) - 0.5 | 
            
                                                                                                            
                            
            
                                    
            
            
                | 312 |  |  |         first_point = nib.affines.apply_affine(self.affine, first_index) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 313 |  |  |         last_point = nib.affines.apply_affine(self.affine, last_index) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 314 |  |  |         array = np.array((first_point, last_point)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 315 |  |  |         bounds_x, bounds_y, bounds_z = array.T.tolist() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 316 |  |  |         return bounds_x, bounds_y, bounds_z | 
            
                                                                                                            
                            
            
                                    
            
            
                | 317 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 318 |  |  |     @staticmethod | 
            
                                                                                                            
                            
            
                                    
            
            
                | 319 |  |  |     def _parse_single_path( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 320 |  |  |             path: TypePath | 
            
                                                                                                            
                            
            
                                    
            
            
                | 321 |  |  |             ) -> Path: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 322 |  |  |         try: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 323 |  |  |             path = Path(path).expanduser() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 324 |  |  |         except TypeError: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 325 |  |  |             message = ( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 326 |  |  |                 f'Expected type str or Path but found {path} with ' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 327 |  |  |                 f'{type(path)} instead' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 328 |  |  |             ) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 329 |  |  |             raise TypeError(message) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 330 |  |  |         except RuntimeError: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 331 |  |  |             message = ( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 332 |  |  |                 f'Conversion to path not possible for variable: {path}' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 333 |  |  |             ) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 334 |  |  |             raise RuntimeError(message) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 335 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 336 |  |  |         if not (path.is_file() or path.is_dir()):   # might be a dir with DICOM | 
            
                                                                                                            
                            
            
                                    
            
            
                | 337 |  |  |             raise FileNotFoundError(f'File not found: "{path}"') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 338 |  |  |         return path | 
            
                                                                                                            
                            
            
                                    
            
            
                | 339 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 340 |  |  |     def _parse_path( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 341 |  |  |             self, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 342 |  |  |             path: Union[TypePath, Sequence[TypePath]] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 343 |  |  |             ) -> Optional[Union[Path, List[Path]]]: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 344 |  |  |         if path is None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 345 |  |  |             return None | 
            
                                                                                                            
                            
            
                                    
            
            
                | 346 |  |  |         if isinstance(path, (str, Path)): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 347 |  |  |             return self._parse_single_path(path) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 348 |  |  |         else: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 349 |  |  |             return [self._parse_single_path(p) for p in path] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 350 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 351 |  |  |     def _parse_tensor( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 352 |  |  |             self, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 353 |  |  |             tensor: TypeData, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 354 |  |  |             none_ok: bool = True, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 355 |  |  |             ) -> torch.Tensor: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 356 |  |  |         if tensor is None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 357 |  |  |             if none_ok: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 358 |  |  |                 return None | 
            
                                                                                                            
                            
            
                                    
            
            
                | 359 |  |  |             else: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 360 |  |  |                 raise RuntimeError('Input tensor cannot be None') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 361 |  |  |         if isinstance(tensor, np.ndarray): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 362 |  |  |             tensor = check_uint_to_int(tensor) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 363 |  |  |             tensor = torch.from_numpy(tensor) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 364 |  |  |         elif not isinstance(tensor, torch.Tensor): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 365 |  |  |             message = 'Input tensor must be a PyTorch tensor or NumPy array' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 366 |  |  |             raise TypeError(message) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 367 |  |  |         if tensor.ndim != 4: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 368 |  |  |             raise ValueError('Input tensor must be 4D') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 369 |  |  |         if tensor.dtype == torch.bool: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 370 |  |  |             tensor = tensor.to(torch.uint8) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 371 |  |  |         if self.check_nans and torch.isnan(tensor).any(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 372 |  |  |             warnings.warn(f'NaNs found in tensor', RuntimeWarning) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 373 |  |  |         return tensor | 
            
                                                                                                            
                            
            
                                    
            
            
                | 374 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 375 |  |  |     def parse_tensor_shape(self, tensor: torch.Tensor) -> torch.Tensor: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 376 |  |  |         return ensure_4d(tensor) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 377 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 378 |  |  |     @staticmethod | 
            
                                                                                                            
                            
            
                                    
            
            
                | 379 |  |  |     def _parse_affine(affine: np.ndarray) -> np.ndarray: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 380 |  |  |         if affine is None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 381 |  |  |             return np.eye(4) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 382 |  |  |         if not isinstance(affine, np.ndarray): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 383 |  |  |             raise TypeError(f'Affine must be a NumPy array, not {type(affine)}') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 384 |  |  |         if affine.shape != (4, 4): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 385 |  |  |             raise ValueError(f'Affine shape must be (4, 4), not {affine.shape}') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 386 |  |  |         return affine | 
            
                                                                                                            
                            
            
                                    
            
            
                | 387 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 388 |  |  |     def load(self) -> None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 389 |  |  |         r"""Load the image from disk. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 390 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 391 |  |  |         Returns: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 392 |  |  |             Tuple containing a 4D tensor of size :math:`(C, W, H, D)` and a 2D | 
            
                                                                                                            
                            
            
                                    
            
            
                | 393 |  |  |             :math:`4 \times 4` affine matrix to convert voxel indices to world | 
            
                                                                                                            
                            
            
                                    
            
            
                | 394 |  |  |             coordinates. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 395 |  |  |         """ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 396 |  |  |         if self._loaded: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 397 |  |  |             return | 
            
                                                                                                            
                            
            
                                    
            
            
                | 398 |  |  |         paths = self.path if isinstance(self.path, list) else [self.path] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 399 |  |  |         tensor, affine = self.read_and_check(paths[0]) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 400 |  |  |         tensors = [tensor] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 401 |  |  |         for path in paths[1:]: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 402 |  |  |             new_tensor, new_affine = self.read_and_check(path) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 403 |  |  |             if not np.array_equal(affine, new_affine): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 404 |  |  |                 message = ( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 405 |  |  |                     'Files have different affine matrices.' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 406 |  |  |                     f'\nMatrix of {paths[0]}:' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 407 |  |  |                     f'\n{affine}' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 408 |  |  |                     f'\nMatrix of {path}:' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 409 |  |  |                     f'\n{new_affine}' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 410 |  |  |                 ) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 411 |  |  |                 warnings.warn(message, RuntimeWarning) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 412 |  |  |             if not tensor.shape[1:] == new_tensor.shape[1:]: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 413 |  |  |                 message = ( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 414 |  |  |                     f'Files shape do not match, found {tensor.shape}' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 415 |  |  |                     f'and {new_tensor.shape}' | 
            
                                                                                                            
                            
            
                                    
            
            
                | 416 |  |  |                 ) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 417 |  |  |                 RuntimeError(message) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 418 |  |  |             tensors.append(new_tensor) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 419 |  |  |         tensor = torch.cat(tensors) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 420 |  |  |         self.data = tensor | 
            
                                                                                                            
                            
            
                                    
            
            
                | 421 |  |  |         self.affine = affine | 
            
                                                                                                            
                            
            
                                    
            
            
                | 422 |  |  |         self._loaded = True | 
            
                                                                                                            
                            
            
                                    
            
            
                | 423 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 424 |  |  |     def read_and_check(self, path: TypePath) -> Tuple[torch.Tensor, np.ndarray]: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 425 |  |  |         tensor, affine = read_image(path) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 426 |  |  |         tensor = self.parse_tensor_shape(tensor) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 427 |  |  |         if self.channels_last: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 428 |  |  |             tensor = tensor.permute(3, 0, 1, 2) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 429 |  |  |         if self.check_nans and torch.isnan(tensor).any(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 430 |  |  |             warnings.warn(f'NaNs found in file "{path}"', RuntimeWarning) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 431 |  |  |         return tensor, affine | 
            
                                                                                                            
                            
            
                                    
            
            
                | 432 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 433 |  |  |     def save(self, path: TypePath, squeeze: bool = True) -> None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 434 |  |  |         """Save image to disk. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 435 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 436 |  |  |         Args: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 437 |  |  |             path: String or instance of :class:`pathlib.Path`. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 438 |  |  |             squeeze: If ``True``, singleton dimensions will be removed | 
            
                                                                                                            
                            
            
                                    
            
            
                | 439 |  |  |                 before saving. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 440 |  |  |         """ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 441 |  |  |         write_image( | 
            
                                                                                                            
                            
            
                                    
            
            
                | 442 |  |  |             self.data, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 443 |  |  |             self.affine, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 444 |  |  |             path, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 445 |  |  |             squeeze=squeeze, | 
            
                                                                                                            
                            
            
                                    
            
            
                | 446 |  |  |         ) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 447 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 448 |  |  |     def is_2d(self) -> bool: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 449 |  |  |         return self.shape[-1] == 1 | 
            
                                                                                                            
                            
            
                                    
            
            
                | 450 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 451 |  |  |     def numpy(self) -> np.ndarray: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 452 |  |  |         """Get a NumPy array containing the image data.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 453 |  |  |         return np.asarray(self) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 454 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 455 |  |  |     def as_sitk(self, **kwargs) -> sitk.Image: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 456 |  |  |         """Get the image as an instance of :class:`sitk.Image`.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 457 |  |  |         return nib_to_sitk(self.data, self.affine, **kwargs) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 458 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 459 |  |  |     def as_pil(self) -> ImagePIL: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 460 |  |  |         """Get the image as an instance of :class:`PIL.Image`. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 461 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 462 |  |  |         .. note:: Values will be clamped to 0-255 and cast to uint8. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 463 |  |  |         """ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 464 |  |  |         self.check_is_2d() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 465 |  |  |         tensor = self.data | 
            
                                                                                                            
                            
            
                                    
            
            
                | 466 |  |  |         if len(tensor) == 1: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 467 |  |  |             tensor = torch.cat(3 * [tensor]) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 468 |  |  |         if len(tensor) != 3: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 469 |  |  |             raise RuntimeError('The image must have 1 or 3 channels') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 470 |  |  |         tensor = tensor.permute(3, 1, 2, 0)[0] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 471 |  |  |         array = tensor.clamp(0, 255).numpy() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 472 |  |  |         return ImagePIL.fromarray(array.astype(np.uint8)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 473 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 474 |  |  |     def get_center(self, lps: bool = False) -> TypeTripletFloat: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 475 |  |  |         """Get image center in RAS+ or LPS+ coordinates. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 476 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 477 |  |  |         Args: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 478 |  |  |             lps: If ``True``, the coordinates will be in LPS+ orientation, i.e. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 479 |  |  |                 the first dimension grows towards the left, etc. Otherwise, the | 
            
                                                                                                            
                            
            
                                    
            
            
                | 480 |  |  |                 coordinates will be in RAS+ orientation. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 481 |  |  |         """ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 482 |  |  |         size = np.array(self.spatial_shape) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 483 |  |  |         center_index = (size - 1) / 2 | 
            
                                                                                                            
                            
            
                                    
            
            
                | 484 |  |  |         r, a, s = nib.affines.apply_affine(self.affine, center_index) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 485 |  |  |         if lps: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 486 |  |  |             return (-r, -a, s) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 487 |  |  |         else: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 488 |  |  |             return (r, a, s) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 489 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 490 |  |  |     def set_check_nans(self, check_nans: bool) -> None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 491 |  |  |         self.check_nans = check_nans | 
            
                                                                                                            
                            
            
                                    
            
            
                | 492 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 493 |  |  |     def plot(self, **kwargs) -> None: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 494 |  |  |         """Plot image.""" | 
            
                                                                                                            
                            
            
                                    
            
            
                | 495 |  |  |         if self.is_2d(): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 496 |  |  |             self.as_pil().show() | 
            
                                                                                                            
                            
            
                                    
            
            
                | 497 |  |  |         else: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 498 |  |  |             from ..visualization import plot_volume  # avoid circular import | 
            
                                                                                                            
                            
            
                                    
            
            
                | 499 |  |  |             plot_volume(self, **kwargs) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 500 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 501 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 502 |  |  | class ScalarImage(Image): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 503 |  |  |     """Image whose pixel values represent scalars. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 504 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 505 |  |  |     Example: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 506 |  |  |         >>> import torch | 
            
                                                                                                            
                            
            
                                    
            
            
                | 507 |  |  |         >>> import torchio as tio | 
            
                                                                                                            
                            
            
                                    
            
            
                | 508 |  |  |         >>> # Loading from a file | 
            
                                                                                                            
                            
            
                                    
            
            
                | 509 |  |  |         >>> t1_image = tio.ScalarImage('t1.nii.gz') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 510 |  |  |         >>> dmri = tio.ScalarImage(tensor=torch.rand(32, 128, 128, 88)) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 511 |  |  |         >>> image = tio.ScalarImage('safe_image.nrrd', check_nans=False) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 512 |  |  |         >>> data, affine = image.data, image.affine | 
            
                                                                                                            
                            
            
                                    
            
            
                | 513 |  |  |         >>> affine.shape | 
            
                                                                                                            
                            
            
                                    
            
            
                | 514 |  |  |         (4, 4) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 515 |  |  |         >>> image.data is image[tio.DATA] | 
            
                                                                                                            
                            
            
                                    
            
            
                | 516 |  |  |         True | 
            
                                                                                                            
                            
            
                                    
            
            
                | 517 |  |  |         >>> image.data is image.tensor | 
            
                                                                                                            
                            
            
                                    
            
            
                | 518 |  |  |         True | 
            
                                                                                                            
                            
            
                                    
            
            
                | 519 |  |  |         >>> type(image.data) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 520 |  |  |         torch.Tensor | 
            
                                                                                                            
                            
            
                                    
            
            
                | 521 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 522 |  |  |     See :class:`~torchio.Image` for more information. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 523 |  |  |     """ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 524 |  |  |     def __init__(self, *args, **kwargs): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 525 |  |  |         if 'type' in kwargs and kwargs['type'] != INTENSITY: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 526 |  |  |             raise ValueError('Type of ScalarImage is always torchio.INTENSITY') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 527 |  |  |         kwargs.update({'type': INTENSITY}) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 528 |  |  |         super().__init__(*args, **kwargs) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 529 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 530 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 531 |  |  | class LabelMap(Image): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 532 |  |  |     """Image whose pixel values represent categorical labels. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 533 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 534 |  |  |     Intensity transforms are not applied to these images. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 535 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 536 |  |  |     Example: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 537 |  |  |         >>> import torch | 
            
                                                                                                            
                            
            
                                    
            
            
                | 538 |  |  |         >>> import torchio as tio | 
            
                                                                                                            
                            
            
                                    
            
            
                | 539 |  |  |         >>> labels = tio.LabelMap(tensor=torch.rand(1, 128, 128, 68) > 0.5) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 540 |  |  |         >>> labels = tio.LabelMap('t1_seg.nii.gz')  # loading from a file | 
            
                                                                                                            
                            
            
                                    
            
            
                | 541 |  |  |         >>> tpm = tio.LabelMap(                     # loading from files | 
            
                                                                                                            
                            
            
                                    
            
            
                | 542 |  |  |         ...     'gray_matter.nii.gz', | 
            
                                                                                                            
                            
            
                                    
            
            
                | 543 |  |  |         ...     'white_matter.nii.gz', | 
            
                                                                                                            
                            
            
                                    
            
            
                | 544 |  |  |         ...     'csf.nii.gz', | 
            
                                                                                                            
                            
            
                                    
            
            
                | 545 |  |  |         ... ) | 
            
                                                                                                            
                            
            
                                    
            
            
                | 546 |  |  |  | 
            
                                                                                                            
                            
            
                                    
            
            
                | 547 |  |  |     See :class:`~torchio.Image` for more information. | 
            
                                                                                                            
                            
            
                                    
            
            
                | 548 |  |  |     """ | 
            
                                                                                                            
                            
            
                                    
            
            
                | 549 |  |  |     def __init__(self, *args, **kwargs): | 
            
                                                                                                            
                            
            
                                    
            
            
                | 550 |  |  |         if 'type' in kwargs and kwargs['type'] != LABEL: | 
            
                                                                                                            
                            
            
                                    
            
            
                | 551 |  |  |             raise ValueError('Type of LabelMap is always torchio.LABEL') | 
            
                                                                                                            
                            
            
                                    
            
            
                | 552 |  |  |         kwargs.update({'type': LABEL}) | 
            
                                                                                                            
                                                                
            
                                    
            
            
                | 553 |  |  |         super().__init__(*args, **kwargs) | 
            
                                                        
            
                                    
            
            
                | 554 |  |  |  |