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                import random  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                import warnings  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from itertools import islice  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from typing import List, Iterator, Optional  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                import humanize  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from tqdm import trange  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from torch.utils.data import Dataset, DataLoader  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from .subject import Subject  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from .sampler import PatchSampler  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from .dataset import SubjectsDataset  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                class Queue(Dataset):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    r"""Queue used for stochastic patch-based training.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    A training iteration (i.e., forward and backward pass) performed on a  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    GPU is usually faster than loading, preprocessing, augmenting, and cropping  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    a volume on a CPU.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    Most preprocessing operations could be performed using a GPU,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    but these devices are typically reserved for training the CNN so that batch  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    size and input tensor size can be as large as possible.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    Therefore, it is beneficial to prepare (i.e., load, preprocess and augment)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    the volumes using multiprocessing CPU techniques in parallel with the  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    forward-backward passes of a training iteration.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    Once a volume is appropriately prepared, it is computationally beneficial to  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    sample multiple patches from a volume rather than having to prepare the same  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    volume each time a patch needs to be extracted.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    The sampled patches are then stored in a buffer or *queue* until  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    the next training iteration, at which point they are loaded onto the GPU  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    for inference.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    For this, TorchIO provides the :class:`~torchio.data.Queue` class, which also  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    inherits from the PyTorch :class:`~torch.utils.data.Dataset`.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    In this queueing system,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    samplers behave as generators that yield patches from random locations  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    in volumes contained in the :class:`~torchio.data.SubjectsDataset`.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    The end of a training epoch is defined as the moment after which patches  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    from all subjects have been used for training.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    At the beginning of each training epoch,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    the subjects list in the :class:`~torchio.data.SubjectsDataset` is shuffled,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    as is typically done in machine learning pipelines to increase variance  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    of training instances during model optimization.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    A PyTorch loader queries the datasets copied in each process,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    which load and process the volumes in parallel on the CPU.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    A patches list is filled with patches extracted by the sampler,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    and the queue is shuffled once it has reached a specified maximum length so  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    that batches are composed of patches from different subjects.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    The internal data loader continues querying the  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    :class:`~torchio.data.SubjectsDataset` using multiprocessing.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    The patches list, when emptied, is refilled with new patches.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    A second data loader, external to the queue,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    may be used to collate batches of patches stored in the queue,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    which are passed to the neural network.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    Args:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        subjects_dataset: Instance of :class:`~torchio.data.SubjectsDataset`.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        max_length: Maximum number of patches that can be stored in the queue.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            Using a large number means that the queue needs to be filled less  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            often, but more CPU memory is needed to store the patches.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        samples_per_volume: Number of patches to extract from each volume.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            A small number of patches ensures a large variability in the queue,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            but training will be slower.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        sampler: A subclass of :class:`~torchio.data.sampler.PatchSampler` used  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            to extract patches from the volumes.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        num_workers: Number of subprocesses to use for data loading  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            (as in :class:`torch.utils.data.DataLoader`).  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            ``0`` means that the data will be loaded in the main process.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        shuffle_subjects: If ``True``, the subjects dataset is shuffled at the  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            beginning of each epoch, i.e. when all patches from all subjects  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            have been processed.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        shuffle_patches: If ``True``, patches are shuffled after filling the  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            queue.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        start_background: If ``True``, the loader will start working in the  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            background as soon as the queue is instantiated.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        verbose: If ``True``, some debugging messages will be printed.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    This diagram represents the connection between  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    a :class:`~torchio.data.SubjectsDataset`,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    a :class:`~torchio.data.Queue`  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    and the :class:`~torch.utils.data.DataLoader` used to pop batches from the  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    queue.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    .. image:: https://raw.githubusercontent.com/fepegar/torchio/master/docs/images/diagram_patches.svg  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        :alt: Training with patches  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    This sketch can be used to experiment and understand how the queue works.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    In this case, :attr:`shuffle_subjects` is ``False``  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    and :attr:`shuffle_patches` is ``True``.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    .. raw:: html  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        <embed>  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            <iframe style="width: 640px; height: 360px; overflow: hidden;" scrolling="no" frameborder="0" src="https://editor.p5js.org/embed/DZwjZzkkV"></iframe>  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        </embed>  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    .. note:: :attr:`num_workers` refers to the number of workers used to  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        load and transform the volumes. Multiprocessing is not needed to pop  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        patches from the queue, so you should always use ``num_workers=0`` for  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        the :class:`~torch.utils.data.DataLoader` you instantiate to generate  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        training batches.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    Example:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> import torch  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> import torchio as tio  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> from torch.utils.data import DataLoader  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> patch_size = 96  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> queue_length = 300  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> samples_per_volume = 10  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> sampler = tio.data.UniformSampler(patch_size)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> subject = tio.datasets.Colin27()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> subjects_dataset = tio.SubjectsDataset(10 * [subject])  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> patches_queue = tio.Queue(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    ...     subjects_dataset,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    ...     queue_length,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    ...     samples_per_volume,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    ...     sampler,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    ...     num_workers=4,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    ... )  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> patches_loader = DataLoader(patches_queue, batch_size=16)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> num_epochs = 2  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> model = torch.nn.Identity()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    >>> for epoch_index in range(num_epochs):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    ...     for patches_batch in patches_loader:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    ...         inputs = patches_batch['t1'][tio.DATA]  # key 't1' is in subject  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    128
                 | 
                                    
                                                     | 
                
                 | 
                    ...         targets = patches_batch['brain'][tio.DATA]  # key 'brain' is in subject  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    129
                 | 
                                    
                                                     | 
                
                 | 
                    ...         logits = model(inputs)  # model being an instance of torch.nn.Module  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    130
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    131
                 | 
                                    
                                                     | 
                
                 | 
                    """  # noqa: E501  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    132
                 | 
                                    
                                                     | 
                
                 | 
                    def __init__(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    133
                 | 
                                    
                                                     | 
                
                 | 
                            self,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    134
                 | 
                                    
                                                     | 
                
                 | 
                            subjects_dataset: SubjectsDataset,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    135
                 | 
                                    
                                                     | 
                
                 | 
                            max_length: int,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    136
                 | 
                                    
                                                     | 
                
                 | 
                            samples_per_volume: int,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    137
                 | 
                                    
                                                     | 
                
                 | 
                            sampler: PatchSampler,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    138
                 | 
                                    
                                                     | 
                
                 | 
                            num_workers: int = 0,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    139
                 | 
                                    
                                                     | 
                
                 | 
                            shuffle_subjects: bool = True,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    140
                 | 
                                    
                                                     | 
                
                 | 
                            shuffle_patches: bool = True,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    141
                 | 
                                    
                                                     | 
                
                 | 
                            start_background: bool = True,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    142
                 | 
                                    
                                                     | 
                
                 | 
                            verbose: bool = False,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    143
                 | 
                                    
                                                     | 
                
                 | 
                            ):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    144
                 | 
                                    
                                                     | 
                
                 | 
                        self.subjects_dataset = subjects_dataset  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    145
                 | 
                                    
                                                     | 
                
                 | 
                        self.max_length = max_length  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    146
                 | 
                                    
                                                     | 
                
                 | 
                        self.shuffle_subjects = shuffle_subjects  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    147
                 | 
                                    
                                                     | 
                
                 | 
                        self.shuffle_patches = shuffle_patches  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    148
                 | 
                                    
                                                     | 
                
                 | 
                        self.samples_per_volume = samples_per_volume  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    149
                 | 
                                    
                                                     | 
                
                 | 
                        self.sampler = sampler  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    150
                 | 
                                    
                                                     | 
                
                 | 
                        self.num_workers = num_workers  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    151
                 | 
                                    
                                                     | 
                
                 | 
                        self.verbose = verbose  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    152
                 | 
                                    
                                                     | 
                
                 | 
                        self._subjects_iterable = None  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    153
                 | 
                                    
                                                     | 
                
                 | 
                        if start_background:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    154
                 | 
                                    
                                                     | 
                
                 | 
                            self._initialize_subjects_iterable()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    155
                 | 
                                    
                                                     | 
                
                 | 
                        self.patches_list: List[Subject] = []  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    156
                 | 
                                    
                                                     | 
                
                 | 
                        self.num_sampled_patches = 0  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    157
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    158
                 | 
                                    
                                                     | 
                
                 | 
                    def __len__(self):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    159
                 | 
                                    
                                                     | 
                
                 | 
                        return self.iterations_per_epoch  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    160
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    161
                 | 
                                    
                                                     | 
                
                 | 
                    def __getitem__(self, _):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    162
                 | 
                                    
                                                     | 
                
                 | 
                        # There are probably more elegant ways of doing this  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    163
                 | 
                                    
                                                     | 
                
                 | 
                        if not self.patches_list:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    164
                 | 
                                    
                                                     | 
                
                 | 
                            self._print('Patches list is empty.') | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    165
                 | 
                                    
                                                     | 
                
                 | 
                            self._fill()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    166
                 | 
                                    
                                                     | 
                
                 | 
                        sample_patch = self.patches_list.pop()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    167
                 | 
                                    
                                                     | 
                
                 | 
                        self.num_sampled_patches += 1  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    168
                 | 
                                    
                                                     | 
                
                 | 
                        return sample_patch  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    169
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    170
                 | 
                                    
                                                     | 
                
                 | 
                    def __repr__(self):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    171
                 | 
                                    
                                                     | 
                
                 | 
                        attributes = [  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    172
                 | 
                                    
                                                     | 
                
                 | 
                            f'max_length={self.max_length}', | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    173
                 | 
                                    
                                                     | 
                
                 | 
                            f'num_subjects={self.num_subjects}', | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    174
                 | 
                                    
                                                     | 
                
                 | 
                            f'num_patches={self.num_patches}', | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    175
                 | 
                                    
                                                     | 
                
                 | 
                            f'samples_per_volume={self.samples_per_volume}', | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    176
                 | 
                                    
                                                     | 
                
                 | 
                            f'num_sampled_patches={self.num_sampled_patches}', | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    177
                 | 
                                    
                                                     | 
                
                 | 
                            f'iterations_per_epoch={self.iterations_per_epoch}', | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    178
                 | 
                                    
                                                     | 
                
                 | 
                        ]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    179
                 | 
                                    
                                                     | 
                
                 | 
                        attributes_string = ', '.join(attributes)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    180
                 | 
                                    
                                                     | 
                
                 | 
                        return f'Queue({attributes_string})' | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    181
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    182
                 | 
                                    
                                                     | 
                
                 | 
                    def _print(self, *args):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    183
                 | 
                                    
                                                     | 
                
                 | 
                        if self.verbose:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    184
                 | 
                                    
                                                     | 
                
                 | 
                            print(*args)  # noqa: T001  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    185
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    186
                 | 
                                    
                                                     | 
                
                 | 
                    def _initialize_subjects_iterable(self):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    187
                 | 
                                    
                                                     | 
                
                 | 
                        self._subjects_iterable = self._get_subjects_iterable()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    188
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    189
                 | 
                                    
                                                     | 
                
                 | 
                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    190
                 | 
                                    
                                                     | 
                
                 | 
                    def subjects_iterable(self):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    191
                 | 
                                    
                                                     | 
                
                 | 
                        if self._subjects_iterable is None:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    192
                 | 
                                    
                                                     | 
                
                 | 
                            self._initialize_subjects_iterable()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    193
                 | 
                                    
                                                     | 
                
                 | 
                        return self._subjects_iterable  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    194
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    195
                 | 
                                    
                                                     | 
                
                 | 
                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    196
                 | 
                                    
                                                     | 
                
                 | 
                    def num_subjects(self) -> int:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    197
                 | 
                                    
                                                     | 
                
                 | 
                        return len(self.subjects_dataset)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    198
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    199
                 | 
                                    
                                                     | 
                
                 | 
                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    200
                 | 
                                    
                                                     | 
                
                 | 
                    def num_patches(self) -> int:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    201
                 | 
                                    
                                                     | 
                
                 | 
                        return len(self.patches_list)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    202
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    203
                 | 
                                    
                                                     | 
                
                 | 
                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    204
                 | 
                                    
                                                     | 
                
                 | 
                    def iterations_per_epoch(self) -> int:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    205
                 | 
                                    
                                                     | 
                
                 | 
                        return self.num_subjects * self.samples_per_volume  | 
            
            
                                                                                                            
                                                                
            
                                    
            
            
                | 
                    206
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    207
                 | 
                                    
                                                     | 
                
                 | 
                    def _fill(self) -> None:  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    208
                 | 
                                    
                                                     | 
                
                 | 
                        assert self.sampler is not None  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    209
                 | 
                                    
                                                     | 
                
                 | 
                        if self.max_length % self.samples_per_volume != 0:  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    210
                 | 
                                    
                                                     | 
                
                 | 
                            message = (  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    211
                 | 
                                    
                                                     | 
                
                 | 
                                f'Queue length ({self.max_length})' | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    212
                 | 
                                    
                                                     | 
                
                 | 
                                ' not divisible by the number of'  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    213
                 | 
                                    
                                                     | 
                
                 | 
                                f' patches per volume ({self.samples_per_volume})' | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    214
                 | 
                                    
                                                     | 
                
                 | 
                            )  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    215
                 | 
                                    
                                                     | 
                
                 | 
                            warnings.warn(message, RuntimeWarning)  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    216
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    217
                 | 
                                    
                                                     | 
                
                 | 
                        # If there are e.g. 4 subjects and 1 sample per volume and max_length  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    218
                 | 
                                    
                                                     | 
                
                 | 
                        # is 6, we just need to load 4 subjects, not 6  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    219
                 | 
                                    
                                                     | 
                
                 | 
                        max_num_subjects_for_queue = self.max_length // self.samples_per_volume  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    220
                 | 
                                    
                                                     | 
                
                 | 
                        num_subjects_for_queue = min(  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    221
                 | 
                                    
                                                     | 
                
                 | 
                            self.num_subjects, max_num_subjects_for_queue)  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    222
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    223
                 | 
                                    
                                                     | 
                
                 | 
                        self._print(f'Filling queue from {num_subjects_for_queue} subjects...') | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    224
                 | 
                                    
                                                     | 
                
                 | 
                        if self.verbose:  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    225
                 | 
                                    
                                                     | 
                
                 | 
                            iterable = trange(num_subjects_for_queue, leave=False)  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    226
                 | 
                                    
                                                     | 
                
                 | 
                        else:  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    227
                 | 
                                    
                                                     | 
                
                 | 
                            iterable = range(num_subjects_for_queue)  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    228
                 | 
                                    
                                                     | 
                
                 | 
                        for _ in iterable:  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    229
                 | 
                                    
                                                     | 
                
                 | 
                            subject = self._get_next_subject()  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    230
                 | 
                                    
                                                     | 
                
                 | 
                            iterable = self.sampler(subject)  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    231
                 | 
                                    
                                                     | 
                
                 | 
                            patches = list(islice(iterable, self.samples_per_volume))  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    232
                 | 
                                    
                                                     | 
                
                 | 
                            self.patches_list.extend(patches)  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    233
                 | 
                                    
                                                     | 
                
                 | 
                        if self.shuffle_patches:  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    234
                 | 
                                    
                                                     | 
                
                 | 
                            random.shuffle(self.patches_list)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    235
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    236
                 | 
                                    
                                                     | 
                
                 | 
                    def _get_next_subject(self) -> Subject:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    237
                 | 
                                    
                                                     | 
                
                 | 
                        # A StopIteration exception is expected when the queue is empty  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    238
                 | 
                                    
                                                     | 
                
                 | 
                        try:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    239
                 | 
                                    
                                                     | 
                
                 | 
                            subject = next(self.subjects_iterable)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    240
                 | 
                                    
                                                     | 
                
                 | 
                        except StopIteration as exception:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    241
                 | 
                                    
                                                     | 
                
                 | 
                            self._print('Queue is empty:', exception) | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    242
                 | 
                                    
                                                     | 
                
                 | 
                            self._initialize_subjects_iterable()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    243
                 | 
                                    
                                                     | 
                
                 | 
                            subject = next(self.subjects_iterable)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    244
                 | 
                                    
                                                     | 
                
                 | 
                        return subject  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    245
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    246
                 | 
                                    
                                                     | 
                
                 | 
                    @staticmethod  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    247
                 | 
                                    
                                                     | 
                
                 | 
                    def _get_first_item(batch):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    248
                 | 
                                    
                                                     | 
                
                 | 
                        return batch[0]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    249
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    250
                 | 
                                    
                                                     | 
                
                 | 
                    def _get_subjects_iterable(self) -> Iterator:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    251
                 | 
                                    
                                                     | 
                
                 | 
                        # I need a DataLoader to handle parallelism  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    252
                 | 
                                    
                                                     | 
                
                 | 
                        # But this loader is always expected to yield single subject samples  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    253
                 | 
                                    
                                                     | 
                
                 | 
                        self._print(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    254
                 | 
                                    
                                                     | 
                
                 | 
                            f'\nCreating subjects loader with {self.num_workers} workers') | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    255
                 | 
                                    
                                                     | 
                
                 | 
                        subjects_loader = DataLoader(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    256
                 | 
                                    
                                                     | 
                
                 | 
                            self.subjects_dataset,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    257
                 | 
                                    
                                                     | 
                
                 | 
                            num_workers=self.num_workers,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    258
                 | 
                                    
                                                     | 
                
                 | 
                            batch_size=1,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    259
                 | 
                                    
                                                     | 
                
                 | 
                            collate_fn=self._get_first_item,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    260
                 | 
                                    
                                                     | 
                
                 | 
                            shuffle=self.shuffle_subjects,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    261
                 | 
                                    
                                                     | 
                
                 | 
                        )  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    262
                 | 
                                    
                                                     | 
                
                 | 
                        return iter(subjects_loader)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    263
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    264
                 | 
                                    
                                                     | 
                
                 | 
                    def get_max_memory(self, subject: Optional[Subject] = None) -> int:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    265
                 | 
                                    
                                                     | 
                
                 | 
                        """Get the maximum RAM occupied by the patches queue in bytes.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    266
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    267
                 | 
                                    
                                                     | 
                
                 | 
                        Args:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    268
                 | 
                                    
                                                     | 
                
                 | 
                            subject: Sample subject to compute the size of a patch.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    269
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    270
                 | 
                                    
                                                     | 
                
                 | 
                        images_channels = 0  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    271
                 | 
                                    
                                                     | 
                
                 | 
                        if subject is None:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    272
                 | 
                                    
                                                     | 
                
                 | 
                            subject = self.subjects_dataset[0]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    273
                 | 
                                    
                                                     | 
                
                 | 
                        for image in subject.get_images(intensity_only=False):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    274
                 | 
                                    
                                                     | 
                
                 | 
                            images_channels += len(image.data)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    275
                 | 
                                    
                                                     | 
                
                 | 
                        voxels_in_patch = int(self.sampler.patch_size.prod() * images_channels)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    276
                 | 
                                    
                                                     | 
                
                 | 
                        bytes_per_patch = 4 * voxels_in_patch  # assume float32  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    277
                 | 
                                    
                                                     | 
                
                 | 
                        return int(bytes_per_patch * self.max_length)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    278
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    279
                 | 
                                    
                                                     | 
                
                 | 
                    def get_max_memory_pretty(self, subject: Optional[Subject] = None) -> str:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    280
                 | 
                                    
                                                     | 
                
                 | 
                        """Get human-readable maximum RAM occupied by the patches queue.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    281
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    282
                 | 
                                    
                                                     | 
                
                 | 
                        Args:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    283
                 | 
                                    
                                                     | 
                
                 | 
                            subject: Sample subject to compute the size of a patch.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    284
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    285
                 | 
                                    
                                                     | 
                
                 | 
                        memory = self.get_max_memory(subject=subject)  | 
            
            
                                                                                                            
                                                                
            
                                    
            
            
                | 
                    286
                 | 
                                    
                                                     | 
                
                 | 
                        return humanize.naturalsize(memory, binary=True)  | 
            
            
                                                        
            
                                    
            
            
                | 
                    287
                 | 
                                    
                                                     | 
                
                 | 
                 |