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                from typing import Optional, Generator  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                import numpy as np  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from ...typing import TypePatchSize, TypeTripletInt  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from ...data.subject import Subject  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from ...utils import to_tuple  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                class PatchSampler:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    r"""Base class for TorchIO samplers.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    Args:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        patch_size: Tuple of integers :math:`(w, h, d)` to generate patches  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            of size :math:`w \times h \times d`.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            If a single number :math:`n` is provided, :math:`w = h = d = n`.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    .. warning:: This is an abstract class that should only be instantiated  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        using child classes such as :class:`~torchio.data.UniformSampler` and  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        :class:`~torchio.data.WeightedSampler`.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def __init__(self, patch_size: TypePatchSize):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        patch_size_array = np.array(to_tuple(patch_size, length=3))  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        for n in patch_size_array:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            if n < 1 or not isinstance(n, (int, np.integer)):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                                message = (  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                                    'Patch dimensions must be positive integers,'  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                                    f' not {patch_size_array}' | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                                )  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                                raise ValueError(message)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        self.patch_size = patch_size_array.astype(np.uint16)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def extract_patch(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            self,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            subject: Subject,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            index_ini: TypeTripletInt,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            ) -> Subject:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        cropped_subject = self.crop(subject, index_ini, self.patch_size)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        cropped_subject['index_ini'] = np.array(index_ini).astype(int)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        return cropped_subject  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def crop(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            self,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            subject: Subject,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            index_ini: TypeTripletInt,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            patch_size: TypeTripletInt,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            ) -> Subject:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        transform = self._get_crop_transform(subject, index_ini, patch_size)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        return transform(subject)  | 
            
            
                                                                                                            
                                                                
            
                                    
            
            
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                    @staticmethod  | 
            
            
                                                                        
                            
            
                                    
            
            
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                    def _get_crop_transform(  | 
            
            
                                                                        
                            
            
                                    
            
            
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                            subject,  | 
            
            
                                                                        
                            
            
                                    
            
            
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                            index_ini: TypeTripletInt,  | 
            
            
                                                                        
                            
            
                                    
            
            
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                            patch_size: TypePatchSize,  | 
            
            
                                                                        
                            
            
                                    
            
            
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                            ):  | 
            
            
                                                                        
                            
            
                                    
            
            
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                        from ...transforms.preprocessing.spatial.crop import Crop  | 
            
            
                                                                        
                            
            
                                    
            
            
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                        shape = np.array(subject.spatial_shape, dtype=np.uint16)  | 
            
            
                                                                        
                            
            
                                    
            
            
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                        index_ini = np.array(index_ini, dtype=np.uint16)  | 
            
            
                                                                        
                            
            
                                    
            
            
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                        patch_size = np.array(patch_size, dtype=np.uint16)  | 
            
            
                                                                        
                            
            
                                    
            
            
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                        assert len(index_ini) == 3  | 
            
            
                                                                        
                            
            
                                    
            
            
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                        assert len(patch_size) == 3  | 
            
            
                                                                        
                            
            
                                    
            
            
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                        index_fin = index_ini + patch_size  | 
            
            
                                                                        
                            
            
                                    
            
            
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                        crop_ini = index_ini.tolist()  | 
            
            
                                                                        
                            
            
                                    
            
            
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                        crop_fin = (shape - index_fin).tolist()  | 
            
            
                                                                        
                            
            
                                    
            
            
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                        start = ()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        cropping = sum(zip(crop_ini, crop_fin), start)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        return Crop(cropping)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def __call__(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            self,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            subject: Subject,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            num_patches: Optional[int] = None,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            ) -> Generator[Subject, None, None]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        subject.check_consistent_space()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        if np.any(self.patch_size > subject.spatial_shape):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            message = (  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                                f'Patch size {tuple(self.patch_size)} cannot be' | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                                f' larger than image size {tuple(subject.spatial_shape)}' | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            )  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            raise RuntimeError(message)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        kwargs = {} if num_patches is None else {'num_patches': num_patches} | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        return self._generate_patches(subject, **kwargs)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def _generate_patches(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            self,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            subject: Subject,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            num_patches: Optional[int] = None,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            ) -> Generator[Subject, None, None]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        raise NotImplementedError  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                class RandomSampler(PatchSampler):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    r"""Base class for random samplers.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    Args:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        patch_size: Tuple of integers :math:`(w, h, d)` to generate patches  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            of size :math:`w \times h \times d`.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            If a single number :math:`n` is provided, :math:`w = h = d = n`.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def get_probability_map(self, subject: Subject):  | 
            
            
                                                                                                            
                                                                
            
                                    
            
            
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                        raise NotImplementedError  | 
            
            
                                                        
            
                                    
            
            
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