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                import warnings  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    2
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                from pathlib import Path  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    3
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                from typing import Tuple  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    5
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                import torch  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    6
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                import numpy as np  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    7
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                import nibabel as nib  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    8
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                import SimpleITK as sitk  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from ..constants import REPO_URL  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from ..typing import TypePath, TypeData, TypeTripletInt  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                FLIPXY = np.diag([-1, -1, 1, 1])  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                def read_image(path: TypePath) -> Tuple[torch.Tensor, np.ndarray]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    try:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    19
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                        result = _read_sitk(path)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    20
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                    except RuntimeError:  # try with NiBabel  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    21
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                        try:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    22
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                            result = _read_nibabel(path)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        except nib.loadsave.ImageFileError:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    24
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                            message = (  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    25
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                                f'File "{path}" not understood.' | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    26
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                                ' Check supported formats by at'  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    27
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                                ' https://simpleitk.readthedocs.io/en/master/IO.html#images'  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                                ' and https://nipy.org/nibabel/api.html#file-formats'  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            )  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    30
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                            raise RuntimeError(message)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    31
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                    return result  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    32
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                    33
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                    34
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                def _read_nibabel(path: TypePath) -> Tuple[torch.Tensor, np.ndarray]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    35
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                    img = nib.load(str(path), mmap=False)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    36
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                    data = img.get_fdata(dtype=np.float32)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    37
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                    if data.ndim == 5:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    38
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                        data = data[..., 0, :]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    39
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                        data = data.transpose(3, 0, 1, 2)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    40
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                    data = check_uint_to_int(data)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    41
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                    tensor = torch.as_tensor(data)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    42
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                    affine = img.affine  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    43
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                    return tensor, affine  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    44
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                    45
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                    46
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                def _read_sitk(path: TypePath) -> Tuple[torch.Tensor, np.ndarray]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    47
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                    if Path(path).is_dir():  # assume DICOM  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    48
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                        image = _read_dicom(path)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    49
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                    else:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    50
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                        image = sitk.ReadImage(str(path))  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    51
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                    data, affine = sitk_to_nib(image, keepdim=True)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    52
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                    data = check_uint_to_int(data)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    53
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                    tensor = torch.as_tensor(data)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    54
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                    return tensor, affine  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    55
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                    56
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                    57
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                def _read_dicom(directory: TypePath):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    58
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                    directory = Path(directory)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    59
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                    if not directory.is_dir():  # unreachable if called from _read_sitk  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    60
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                        raise FileNotFoundError(f'Directory "{directory}" not found') | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    61
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                    reader = sitk.ImageSeriesReader()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    62
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                    dicom_names = reader.GetGDCMSeriesFileNames(str(directory))  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    63
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                    if not dicom_names:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    64
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                        message = (  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    65
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                            f'The directory "{directory}"' | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    66
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                            ' does not seem to contain DICOM files'  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    67
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                        )  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    68
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                        raise FileNotFoundError(message)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    69
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                    reader.SetFileNames(dicom_names)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    70
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                    image = reader.Execute()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    71
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                    return image  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    72
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                    73
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                    74
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                def read_shape(path: TypePath) -> Tuple[int, int, int, int]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    75
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                    reader = sitk.ImageFileReader()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    76
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                    reader.SetFileName(str(path))  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    77
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                    reader.ReadImageInformation()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    78
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                    num_channels = reader.GetNumberOfComponents()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    79
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                    spatial_shape = reader.GetSize()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    80
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                    if reader.GetDimension() == 2:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    81
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                        spatial_shape = *spatial_shape, 1  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    82
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                    return (num_channels,) + spatial_shape  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    83
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                    84
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                    85
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                def read_affine(path: TypePath) -> np.ndarray:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    86
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                    reader = sitk.ImageFileReader()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    87
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                    reader.SetFileName(str(path))  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    88
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                    reader.ReadImageInformation()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    89
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                    affine = get_ras_affine_from_sitk_metadata(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    90
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                        reader.GetSpacing(),  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    91
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                        reader.GetDirection(),  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    92
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                        reader.GetOrigin(),  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    93
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                    )  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    94
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                    return affine  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    95
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                    96
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                    97
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                def write_image(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    98
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                        tensor: torch.Tensor,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    99
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                        affine: TypeData,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    100
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                        path: TypePath,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    101
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                        squeeze: bool = True,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    102
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                        ) -> None:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    103
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                    args = tensor, affine, path  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    104
                 | 
                                    
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                    try:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    105
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                        _write_sitk(*args)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    106
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                    except RuntimeError:  # try with NiBabel  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    107
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                        _write_nibabel(*args, squeeze=squeeze)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    108
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                    109
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                | 
                    110
                 | 
                                    
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                def _write_nibabel(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    111
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                        tensor: TypeData,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    112
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                        affine: TypeData,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    113
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                        path: TypePath,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    114
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                        squeeze: bool = False,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    115
                 | 
                                    
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                        ) -> None:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    116
                 | 
                                    
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                    """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    117
                 | 
                                    
                                                     | 
                
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                    Expects a path with an extension that can be used by nibabel.save  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    118
                 | 
                                    
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                    to write a NIfTI-1 image, such as '.nii.gz' or '.img'  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    119
                 | 
                                    
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                    """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    120
                 | 
                                    
                                                     | 
                
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                    assert tensor.ndim == 4  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    121
                 | 
                                    
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                    num_components = tensor.shape[0]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    122
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                | 
                    123
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                                                     | 
                
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                    # NIfTI components must be at the end, in a 5D array  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    124
                 | 
                                    
                                                     | 
                
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                    if num_components == 1:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    125
                 | 
                                    
                                                     | 
                
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                        tensor = tensor[0]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    126
                 | 
                                    
                                                     | 
                
                 | 
                    else:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    127
                 | 
                                    
                                                     | 
                
                 | 
                        tensor = tensor[np.newaxis].permute(2, 3, 4, 0, 1)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    128
                 | 
                                    
                                                     | 
                
                 | 
                    tensor = tensor.squeeze() if squeeze else tensor  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    129
                 | 
                                    
                                                     | 
                
                 | 
                    suffix = Path(str(path).replace('.gz', '')).suffix | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    130
                 | 
                                    
                                                     | 
                
                 | 
                    if '.nii' in suffix:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    131
                 | 
                                    
                                                     | 
                
                 | 
                        img = nib.Nifti1Image(np.asarray(tensor), affine)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    132
                 | 
                                    
                                                     | 
                
                 | 
                    elif '.hdr' in suffix or '.img' in suffix:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    133
                 | 
                                    
                                                     | 
                
                 | 
                        img = nib.Nifti1Pair(np.asarray(tensor), affine)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    134
                 | 
                                    
                                                     | 
                
                 | 
                    else:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    135
                 | 
                                    
                                                     | 
                
                 | 
                        raise nib.loadsave.ImageFileError  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    136
                 | 
                                    
                                                     | 
                
                 | 
                    if num_components > 1:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    137
                 | 
                                    
                                                     | 
                
                 | 
                        img.header.set_intent('vector') | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    138
                 | 
                                    
                                                     | 
                
                 | 
                    img.header['qform_code'] = 1  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    139
                 | 
                                    
                                                     | 
                
                 | 
                    img.header['sform_code'] = 0  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    140
                 | 
                                    
                                                     | 
                
                 | 
                    nib.save(img, str(path))  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    141
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    142
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    143
                 | 
                                    
                                                     | 
                
                 | 
                def _write_sitk(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    144
                 | 
                                    
                                                     | 
                
                 | 
                        tensor: torch.Tensor,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    145
                 | 
                                    
                                                     | 
                
                 | 
                        affine: TypeData,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    146
                 | 
                                    
                                                     | 
                
                 | 
                        path: TypePath,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    147
                 | 
                                    
                                                     | 
                
                 | 
                        use_compression: bool = True,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    148
                 | 
                                    
                                                     | 
                
                 | 
                        ) -> None:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    149
                 | 
                                    
                                                     | 
                
                 | 
                    assert tensor.ndim == 4  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    150
                 | 
                                    
                                                     | 
                
                 | 
                    path = Path(path)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    151
                 | 
                                    
                                                     | 
                
                 | 
                    if path.suffix in ('.png', '.jpg', '.jpeg'): | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    152
                 | 
                                    
                                                     | 
                
                 | 
                        warnings.warn(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    153
                 | 
                                    
                                                     | 
                
                 | 
                            f'Casting to uint 8 before saving to {path}', | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    154
                 | 
                                    
                                                     | 
                
                 | 
                            RuntimeWarning,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    155
                 | 
                                    
                                                     | 
                
                 | 
                        )  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    156
                 | 
                                    
                                                     | 
                
                 | 
                        tensor = tensor.numpy().astype(np.uint8)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    157
                 | 
                                    
                                                     | 
                
                 | 
                    image = nib_to_sitk(tensor, affine)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    158
                 | 
                                    
                                                     | 
                
                 | 
                    sitk.WriteImage(image, str(path), use_compression)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    159
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    160
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    161
                 | 
                                    
                                                     | 
                
                 | 
                def read_matrix(path: TypePath):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    162
                 | 
                                    
                                                     | 
                
                 | 
                    """Read an affine transform and convert to tensor."""  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    163
                 | 
                                    
                                                     | 
                
                 | 
                    path = Path(path)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    164
                 | 
                                    
                                                     | 
                
                 | 
                    suffix = path.suffix  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    165
                 | 
                                    
                                                     | 
                
                 | 
                    if suffix in ('.tfm', '.h5'):  # ITK | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    166
                 | 
                                    
                                                     | 
                
                 | 
                        tensor = _read_itk_matrix(path)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    167
                 | 
                                    
                                                     | 
                
                 | 
                    elif suffix in ('.txt', '.trsf'):  # NiftyReg, blockmatching | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    168
                 | 
                                    
                                                     | 
                
                 | 
                        tensor = _read_niftyreg_matrix(path)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    169
                 | 
                                    
                                                     | 
                
                 | 
                    else:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    170
                 | 
                                    
                                                     | 
                
                 | 
                        raise ValueError(f'Unknown suffix for transform file: "{suffix}"') | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    171
                 | 
                                    
                                                     | 
                
                 | 
                    return tensor  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    172
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    173
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    174
                 | 
                                    
                                                     | 
                
                 | 
                def write_matrix(matrix: torch.Tensor, path: TypePath):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    175
                 | 
                                    
                                                     | 
                
                 | 
                    """Write an affine transform."""  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    176
                 | 
                                    
                                                     | 
                
                 | 
                    path = Path(path)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    177
                 | 
                                    
                                                     | 
                
                 | 
                    suffix = path.suffix  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    178
                 | 
                                    
                                                     | 
                
                 | 
                    if suffix in ('.tfm', '.h5'):  # ITK | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    179
                 | 
                                    
                                                     | 
                
                 | 
                        _write_itk_matrix(matrix, path)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    180
                 | 
                                    
                                                     | 
                
                 | 
                    elif suffix in ('.txt', '.trsf'):  # NiftyReg, blockmatching | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    181
                 | 
                                    
                                                     | 
                
                 | 
                        _write_niftyreg_matrix(matrix, path)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    182
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    183
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    184
                 | 
                                    
                                                     | 
                
                 | 
                def _to_itk_convention(matrix):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    185
                 | 
                                    
                                                     | 
                
                 | 
                    """RAS to LPS"""  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    186
                 | 
                                    
                                                     | 
                
                 | 
                    matrix = np.dot(FLIPXY, matrix)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    187
                 | 
                                    
                                                     | 
                
                 | 
                    matrix = np.dot(matrix, FLIPXY)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    188
                 | 
                                    
                                                     | 
                
                 | 
                    matrix = np.linalg.inv(matrix)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    189
                 | 
                                    
                                                     | 
                
                 | 
                    return matrix  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    190
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    191
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    192
                 | 
                                    
                                                     | 
                
                 | 
                def _from_itk_convention(matrix):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    193
                 | 
                                    
                                                     | 
                
                 | 
                    """LPS to RAS"""  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    194
                 | 
                                    
                                                     | 
                
                 | 
                    matrix = np.dot(matrix, FLIPXY)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    195
                 | 
                                    
                                                     | 
                
                 | 
                    matrix = np.dot(FLIPXY, matrix)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    196
                 | 
                                    
                                                     | 
                
                 | 
                    matrix = np.linalg.inv(matrix)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    197
                 | 
                                    
                                                     | 
                
                 | 
                    return matrix  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    198
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    199
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    200
                 | 
                                    
                                                     | 
                
                 | 
                def _read_itk_matrix(path):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    201
                 | 
                                    
                                                     | 
                
                 | 
                    """Read an affine transform in ITK's .tfm format"""  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    202
                 | 
                                    
                                                     | 
                
                 | 
                    transform = sitk.ReadTransform(str(path))  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    203
                 | 
                                    
                                                     | 
                
                 | 
                    parameters = transform.GetParameters()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    204
                 | 
                                    
                                                     | 
                
                 | 
                    rotation_parameters = parameters[:9]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    205
                 | 
                                    
                                                     | 
                
                 | 
                    rotation_matrix = np.array(rotation_parameters).reshape(3, 3)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    206
                 | 
                                    
                                                     | 
                
                 | 
                    translation_parameters = parameters[9:]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    207
                 | 
                                    
                                                     | 
                
                 | 
                    translation_vector = np.array(translation_parameters).reshape(3, 1)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    208
                 | 
                                    
                                                     | 
                
                 | 
                    matrix = np.hstack([rotation_matrix, translation_vector])  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    209
                 | 
                                    
                                                     | 
                
                 | 
                    homogeneous_matrix_lps = np.vstack([matrix, [0, 0, 0, 1]])  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    210
                 | 
                                    
                                                     | 
                
                 | 
                    homogeneous_matrix_ras = _from_itk_convention(homogeneous_matrix_lps)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    211
                 | 
                                    
                                                     | 
                
                 | 
                    return torch.as_tensor(homogeneous_matrix_ras)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    212
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    213
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    214
                 | 
                                    
                                                     | 
                
                 | 
                def _write_itk_matrix(matrix, tfm_path):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    215
                 | 
                                    
                                                     | 
                
                 | 
                    """The tfm file contains the matrix from floating to reference."""  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    216
                 | 
                                    
                                                     | 
                
                 | 
                    transform = _matrix_to_itk_transform(matrix)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    217
                 | 
                                    
                                                     | 
                
                 | 
                    transform.WriteTransform(str(tfm_path))  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    218
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    219
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    220
                 | 
                                    
                                                     | 
                
                 | 
                def _matrix_to_itk_transform(matrix, dimensions=3):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    221
                 | 
                                    
                                                     | 
                
                 | 
                    matrix = _to_itk_convention(matrix)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    222
                 | 
                                    
                                                     | 
                
                 | 
                    rotation = matrix[:dimensions, :dimensions].ravel().tolist()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    223
                 | 
                                    
                                                     | 
                
                 | 
                    translation = matrix[:dimensions, 3].tolist()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    224
                 | 
                                    
                                                     | 
                
                 | 
                    transform = sitk.AffineTransform(rotation, translation)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    225
                 | 
                                    
                                                     | 
                
                 | 
                    return transform  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    226
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    227
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    228
                 | 
                                    
                                                     | 
                
                 | 
                def _read_niftyreg_matrix(trsf_path):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    229
                 | 
                                    
                                                     | 
                
                 | 
                    """Read a NiftyReg matrix and return it as a NumPy array"""  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    230
                 | 
                                    
                                                     | 
                
                 | 
                    matrix = np.loadtxt(trsf_path)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    231
                 | 
                                    
                                                     | 
                
                 | 
                    matrix = np.linalg.inv(matrix)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    232
                 | 
                                    
                                                     | 
                
                 | 
                    return torch.as_tensor(matrix)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    233
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    234
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    235
                 | 
                                    
                                                     | 
                
                 | 
                def _write_niftyreg_matrix(matrix, txt_path):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    236
                 | 
                                    
                                                     | 
                
                 | 
                    """Write an affine transform in NiftyReg's .txt format (ref -> flo)"""  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    237
                 | 
                                    
                                                     | 
                
                 | 
                    matrix = np.linalg.inv(matrix)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    238
                 | 
                                    
                                                     | 
                
                 | 
                    np.savetxt(txt_path, matrix, fmt='%.8f')  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    239
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    240
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    241
                 | 
                                    
                                                     | 
                
                 | 
                def get_rotation_and_spacing_from_affine(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    242
                 | 
                                    
                                                     | 
                
                 | 
                        affine: np.ndarray,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    243
                 | 
                                    
                                                     | 
                
                 | 
                        ) -> Tuple[np.ndarray, np.ndarray]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    244
                 | 
                                    
                                                     | 
                
                 | 
                    # From https://github.com/nipy/nibabel/blob/master/nibabel/orientations.py  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    245
                 | 
                                    
                                                     | 
                
                 | 
                    rotation_zoom = affine[:3, :3]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    246
                 | 
                                    
                                                     | 
                
                 | 
                    spacing = np.sqrt(np.sum(rotation_zoom * rotation_zoom, axis=0))  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    247
                 | 
                                    
                                                     | 
                
                 | 
                    rotation = rotation_zoom / spacing  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    248
                 | 
                                    
                                                     | 
                
                 | 
                    return rotation, spacing  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    249
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    250
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    251
                 | 
                                    
                                                     | 
                
                 | 
                def nib_to_sitk(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    252
                 | 
                                    
                                                     | 
                
                 | 
                        data: TypeData,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    253
                 | 
                                    
                                                     | 
                
                 | 
                        affine: TypeData,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    254
                 | 
                                    
                                                     | 
                
                 | 
                        force_3d: bool = False,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    255
                 | 
                                    
                                                     | 
                
                 | 
                        force_4d: bool = False,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    256
                 | 
                                    
                                                     | 
                
                 | 
                        ) -> sitk.Image:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    257
                 | 
                                    
                                                     | 
                
                 | 
                    """Create a SimpleITK image from a tensor and a 4x4 affine matrix."""  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    258
                 | 
                                    
                                                     | 
                
                 | 
                    if data.ndim != 4:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    259
                 | 
                                    
                                                     | 
                
                 | 
                        shape = tuple(data.shape)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    260
                 | 
                                    
                                                     | 
                
                 | 
                        raise ValueError(f'Input must be 4D, but has shape {shape}') | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    261
                 | 
                                    
                                                     | 
                
                 | 
                    # Possibilities  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    262
                 | 
                                    
                                                     | 
                
                 | 
                    # (1, w, h, 1)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    263
                 | 
                                    
                                                     | 
                
                 | 
                    # (c, w, h, 1)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    264
                 | 
                                    
                                                     | 
                
                 | 
                    # (1, w, h, 1)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    265
                 | 
                                    
                                                     | 
                
                 | 
                    # (c, w, h, d)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    266
                 | 
                                    
                                                     | 
                
                 | 
                    array = np.asarray(data)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    267
                 | 
                                    
                                                     | 
                
                 | 
                    affine = np.asarray(affine).astype(np.float64)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    268
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    269
                 | 
                                    
                                                     | 
                
                 | 
                    is_multichannel = array.shape[0] > 1 and not force_4d  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    270
                 | 
                                    
                                                     | 
                
                 | 
                    is_2d = array.shape[3] == 1 and not force_3d  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    271
                 | 
                                    
                                                     | 
                
                 | 
                    if is_2d:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    272
                 | 
                                    
                                                     | 
                
                 | 
                        array = array[..., 0]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    273
                 | 
                                    
                                                     | 
                
                 | 
                    if not is_multichannel and not force_4d:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    274
                 | 
                                    
                                                     | 
                
                 | 
                        array = array[0]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    275
                 | 
                                    
                                                     | 
                
                 | 
                    array = array.transpose()  # (W, H, D, C) or (W, H, D)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    276
                 | 
                                    
                                                     | 
                
                 | 
                    image = sitk.GetImageFromArray(array, isVector=is_multichannel)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    277
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    278
                 | 
                                    
                                                     | 
                
                 | 
                    rotation, spacing = get_rotation_and_spacing_from_affine(affine)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    279
                 | 
                                    
                                                     | 
                
                 | 
                    flip_xy = np.diag((-1, -1, 1))  # used to switch between LPS and RAS  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    280
                 | 
                                    
                                                     | 
                
                 | 
                    origin = np.dot(flip_xy, affine[:3, 3])  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    281
                 | 
                                    
                                                     | 
                
                 | 
                    direction = np.dot(flip_xy, rotation)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    282
                 | 
                                    
                                                     | 
                
                 | 
                    if is_2d:  # ignore first dimension if 2D (1, W, H, 1)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    283
                 | 
                                    
                                                     | 
                
                 | 
                        direction = direction[:2, :2]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    284
                 | 
                                    
                                                     | 
                
                 | 
                    image.SetOrigin(origin)  # should I add a 4th value if force_4d?  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    285
                 | 
                                    
                                                     | 
                
                 | 
                    image.SetSpacing(spacing)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    286
                 | 
                                    
                                                     | 
                
                 | 
                    image.SetDirection(direction.flatten())  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    287
                 | 
                                    
                                                     | 
                
                 | 
                    if data.ndim == 4:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    288
                 | 
                                    
                                                     | 
                
                 | 
                        assert image.GetNumberOfComponentsPerPixel() == data.shape[0]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    289
                 | 
                                    
                                                     | 
                
                 | 
                    num_spatial_dims = 2 if is_2d else 3  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    290
                 | 
                                    
                                                     | 
                
                 | 
                    assert image.GetSize() == data.shape[1: 1 + num_spatial_dims]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    291
                 | 
                                    
                                                     | 
                
                 | 
                    return image  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    292
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                                                                
            
                                    
            
            
                | 
                    293
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    294
                 | 
                                    
                                                     | 
                
                 | 
                def sitk_to_nib(  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    295
                 | 
                                    
                                                     | 
                
                 | 
                        image: sitk.Image,  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    296
                 | 
                                    
                                                     | 
                
                 | 
                        keepdim: bool = False,  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    297
                 | 
                                    
                                                     | 
                
                 | 
                        ) -> Tuple[np.ndarray, np.ndarray]:  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    298
                 | 
                                    
                                                     | 
                
                 | 
                    data = sitk.GetArrayFromImage(image).transpose()  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    299
                 | 
                                    
                                                     | 
                
                 | 
                    data = check_uint_to_int(data)  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    300
                 | 
                                    
                                                     | 
                
                 | 
                    num_components = image.GetNumberOfComponentsPerPixel()  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    301
                 | 
                                    
                                                     | 
                
                 | 
                    if num_components == 1:  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    302
                 | 
                                    
                                                     | 
                
                 | 
                        data = data[np.newaxis]  # add channels dimension  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    303
                 | 
                                    
                                                     | 
                
                 | 
                    input_spatial_dims = image.GetDimension()  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    304
                 | 
                                    
                                                     | 
                
                 | 
                    if input_spatial_dims == 2:  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    305
                 | 
                                    
                                                     | 
                
                 | 
                        data = data[..., np.newaxis]  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    306
                 | 
                                    
                                                     | 
                
                 | 
                    if not keepdim:  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    307
                 | 
                                    
                                                     | 
                
                 | 
                        data = ensure_4d(data, num_spatial_dims=input_spatial_dims)  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    308
                 | 
                                    
                                                     | 
                
                 | 
                    assert data.shape[0] == num_components  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    309
                 | 
                                    
                                                     | 
                
                 | 
                    assert data.shape[1: 1 + input_spatial_dims] == image.GetSize()  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    310
                 | 
                                    
                                                     | 
                
                 | 
                    affine = get_ras_affine_from_sitk_metadata(  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    311
                 | 
                                    
                                                     | 
                
                 | 
                        image.GetSpacing(),  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    312
                 | 
                                    
                                                     | 
                
                 | 
                        image.GetDirection(),  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    313
                 | 
                                    
                                                     | 
                
                 | 
                        image.GetOrigin(),  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    314
                 | 
                                    
                                                     | 
                
                 | 
                    )  | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    315
                 | 
                                    
                                                     | 
                
                 | 
                    return data, affine  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    316
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    317
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    318
                 | 
                                    
                                                     | 
                
                 | 
                def get_ras_affine_from_sitk_metadata(  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    319
                 | 
                                    
                                                     | 
                
                 | 
                        spacing: TypeTripletInt,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    320
                 | 
                                    
                                                     | 
                
                 | 
                        direction_lps: TypeTripletInt,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    321
                 | 
                                    
                                                     | 
                
                 | 
                        origin_lps: TypeTripletInt,  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    322
                 | 
                                    
                                                     | 
                
                 | 
                        ) -> np.ndarray:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    323
                 | 
                                    
                                                     | 
                
                 | 
                    spacing = np.array(spacing)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    324
                 | 
                                    
                                                     | 
                
                 | 
                    direction = np.array(direction_lps)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    325
                 | 
                                    
                                                     | 
                
                 | 
                    if len(direction) == 9:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    326
                 | 
                                    
                                                     | 
                
                 | 
                        rotation = direction.reshape(3, 3)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    327
                 | 
                                    
                                                     | 
                
                 | 
                    elif len(direction) == 4:  # ignore first dimension if 2D (1, W, H, 1)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    328
                 | 
                                    
                                                     | 
                
                 | 
                        rotation_2d = direction.reshape(2, 2)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    329
                 | 
                                    
                                                     | 
                
                 | 
                        rotation = np.eye(3)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    330
                 | 
                                    
                                                     | 
                
                 | 
                        rotation[:2, :2] = rotation_2d  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    331
                 | 
                                    
                                                     | 
                
                 | 
                        spacing = *spacing, 1  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    332
                 | 
                                    
                                                     | 
                
                 | 
                        origin_lps = *origin_lps, 0  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    333
                 | 
                                    
                                                     | 
                
                 | 
                    else:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    334
                 | 
                                    
                                                     | 
                
                 | 
                        raise RuntimeError(f'Direction not understood: {direction}') | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    335
                 | 
                                    
                                                     | 
                
                 | 
                    flip_xy = np.diag((-1, -1, 1))  # used to switch between LPS and RAS  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    336
                 | 
                                    
                                                     | 
                
                 | 
                    rotation = np.dot(flip_xy, rotation)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    337
                 | 
                                    
                                                     | 
                
                 | 
                    rotation_zoom = rotation * spacing  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    338
                 | 
                                    
                                                     | 
                
                 | 
                    translation = np.dot(flip_xy, origin_lps)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    339
                 | 
                                    
                                                     | 
                
                 | 
                    affine = np.eye(4)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    340
                 | 
                                    
                                                     | 
                
                 | 
                    affine[:3, :3] = rotation_zoom  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    341
                 | 
                                    
                                                     | 
                
                 | 
                    affine[:3, 3] = translation  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    342
                 | 
                                    
                                                     | 
                
                 | 
                    return affine  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    343
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    344
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    345
                 | 
                                    
                                                     | 
                
                 | 
                def ensure_4d(tensor: TypeData, num_spatial_dims=None) -> TypeData:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    346
                 | 
                                    
                                                     | 
                
                 | 
                    # I wish named tensors were properly supported in PyTorch  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    347
                 | 
                                    
                                                     | 
                
                 | 
                    tensor = torch.as_tensor(tensor)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    348
                 | 
                                    
                                                     | 
                
                 | 
                    num_dimensions = tensor.ndim  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    349
                 | 
                                    
                                                     | 
                
                 | 
                    if num_dimensions == 4:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    350
                 | 
                                    
                                                     | 
                
                 | 
                        pass  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    351
                 | 
                                    
                                                     | 
                
                 | 
                    elif num_dimensions == 5:  # hope (W, H, D, 1, C)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    352
                 | 
                                    
                                                     | 
                
                 | 
                        if tensor.shape[-2] == 1:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    353
                 | 
                                    
                                                     | 
                
                 | 
                            tensor = tensor[..., 0, :]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    354
                 | 
                                    
                                                     | 
                
                 | 
                            tensor = tensor.permute(3, 0, 1, 2)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    355
                 | 
                                    
                                                     | 
                
                 | 
                        else:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    356
                 | 
                                    
                                                     | 
                
                 | 
                            raise ValueError('5D is not supported for shape[-2] > 1') | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    357
                 | 
                                    
                                                     | 
                
                 | 
                    elif num_dimensions == 2:  # assume 2D monochannel (W, H)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    358
                 | 
                                    
                                                     | 
                
                 | 
                        tensor = tensor[np.newaxis, ..., np.newaxis]  # (1, W, H, 1)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    359
                 | 
                                    
                                                     | 
                
                 | 
                    elif num_dimensions == 3:  # 2D multichannel or 3D monochannel?  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    360
                 | 
                                    
                                                     | 
                
                 | 
                        if num_spatial_dims == 2:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    361
                 | 
                                    
                                                     | 
                
                 | 
                            tensor = tensor[..., np.newaxis]  # (C, W, H, 1)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    362
                 | 
                                    
                                                     | 
                
                 | 
                        elif num_spatial_dims == 3:  # (W, H, D)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    363
                 | 
                                    
                                                     | 
                
                 | 
                            tensor = tensor[np.newaxis]  # (1, W, H, D)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    364
                 | 
                                    
                                                     | 
                
                 | 
                        else:  # try to guess  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    365
                 | 
                                    
                                                     | 
                
                 | 
                            shape = tensor.shape  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    366
                 | 
                                    
                                                     | 
                
                 | 
                            maybe_rgb = 3 in (shape[0], shape[-1])  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    367
                 | 
                                    
                                                     | 
                
                 | 
                            if maybe_rgb:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    368
                 | 
                                    
                                                     | 
                
                 | 
                                if shape[-1] == 3:  # (W, H, 3)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    369
                 | 
                                    
                                                     | 
                
                 | 
                                    tensor = tensor.permute(2, 0, 1)  # (3, W, H)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    370
                 | 
                                    
                                                     | 
                
                 | 
                                tensor = tensor[..., np.newaxis]  # (3, W, H, 1)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    371
                 | 
                                    
                                                     | 
                
                 | 
                            else:  # (W, H, D)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    372
                 | 
                                    
                                                     | 
                
                 | 
                                tensor = tensor[np.newaxis]  # (1, W, H, D)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    373
                 | 
                                    
                                                     | 
                
                 | 
                    else:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    374
                 | 
                                    
                                                     | 
                
                 | 
                        message = (  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    375
                 | 
                                    
                                                     | 
                
                 | 
                            f'{num_dimensions}D images not supported yet. Please create an' | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    376
                 | 
                                    
                                                     | 
                
                 | 
                            f' issue in {REPO_URL} if you would like support for them' | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    377
                 | 
                                    
                                                     | 
                
                 | 
                        )  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    378
                 | 
                                    
                                                     | 
                
                 | 
                        raise ValueError(message)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    379
                 | 
                                    
                                                     | 
                
                 | 
                    assert tensor.ndim == 4  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    380
                 | 
                                    
                                                     | 
                
                 | 
                    return tensor  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    381
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    382
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    383
                 | 
                                    
                                                     | 
                
                 | 
                def check_uint_to_int(array):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    384
                 | 
                                    
                                                     | 
                
                 | 
                    # This is because PyTorch won't take uint16 nor uint32  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    385
                 | 
                                    
                                                     | 
                
                 | 
                    if array.dtype == np.uint16:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    386
                 | 
                                    
                                                     | 
                
                 | 
                        return array.astype(np.int32)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    387
                 | 
                                    
                                                     | 
                
                 | 
                    if array.dtype == np.uint32:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    388
                 | 
                                    
                                                     | 
                
                 | 
                        return array.astype(np.int64)  | 
            
            
                                                                                                            
                                                                
            
                                    
            
            
                | 
                    389
                 | 
                                    
                                                     | 
                
                 | 
                    return array  | 
            
            
                                                        
            
                                    
            
            
                | 
                    390
                 | 
                                    
                                                     | 
                
                 | 
                 |