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                from __future__ import annotations  | 
            
                            
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                import logging  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from dataclasses import dataclass  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from functools import total_ordering  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from pathlib import Path  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                from typing import List, Mapping, Optional, Sequence, Set, Union  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                import pandas as pd  | 
            
                            
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                from typeddfs import TypedDfs  | 
            
                            
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                logger = logging.getLogger(__package__)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                TaxonomyDf = (  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    TypedDfs.typed("TaxonomyDf").require("taxon").require("parent").require("scientific_name") | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                ).build()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                @total_ordering  | 
            
                            
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                @dataclass()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                class Taxon:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    """"""  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    # we can't use frozen=True because we have both parents and children  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    # instead, just use properties  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    __id: int  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    __name: str  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    __parent: Optional[Taxon]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    __children: Set[Taxon]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def id(self) -> int:  | 
            
                            
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        return self.__id  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def name(self) -> str:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        return self.__name  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def parent(self) -> Taxon:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    54
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    56
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                        return self.__parent  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def children(self) -> Set[Taxon]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        return set(self.__children)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def ancestors(self) -> Sequence[Taxon]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        lst = []  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        self._ancestors(lst)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        return lst  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def descendents(self) -> Sequence[Taxon]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    81
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                    82
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                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    83
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                    84
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                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    85
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                        lst = []  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        self._descendents(lst)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    87
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                        return lst  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def _ancestors(self, values: List[Taxon]) -> None:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    90
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                        values.append(self.parent)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        self.parent._ancestors(values)  | 
            
                            
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                    def _descendents(self, values: List[Taxon]) -> None:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    94
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                        values.extend(self.children)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        for child in self.children:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                            child._descendents(values)  | 
            
                            
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                    def __str__(self):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        return repr(self)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def __repr__(self):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    102
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                        return f"{self.__class__.__name__}({self.id}: {self.name} (parent={self.parent.id if self.parent else 'none'}))" | 
            
                            
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                    def __hash__(self):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    105
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                        return hash(self.id)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    107
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                    def __eq__(self, other):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        return self.id == other.id  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def __lt__(self, other):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                        return self.id < other.id  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    114
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                @dataclass()  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    115
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                class _Taxon(Taxon):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    116
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                    """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    117
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                    An internal, modifiable taxon for building the tree.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    118
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                    """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    def set_name(self, name: str):  | 
            
                            
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                        self.__name = name  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    123
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                    def set_parent(self, parent: _Taxon):  | 
            
                            
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                        self.__parent = parent  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    126
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                    def add_child(self, child: _Taxon):  | 
            
                            
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                    127
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                        self.__children.add(child)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    128
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                    129
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                    # weirdly these are required again -- probably an issue with dataclass  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    130
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                    131
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                    def __str__(self):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
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                    132
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                        return repr(self)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    133
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                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    134
                 | 
                                    
                                                     | 
                
                 | 
                    def __repr__(self):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    135
                 | 
                                    
                                                     | 
                
                 | 
                        return f"{self.__class__.__name__}({self.id}: {self.name} (parent={self.parent.id if self.parent else 'none'}))" | 
            
                            
                    | 
                        
                     | 
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                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
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                | 
                    136
                 | 
                                    
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                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    137
                 | 
                                    
                                                     | 
                
                 | 
                    def __hash__(self):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    138
                 | 
                                    
                                                     | 
                
                 | 
                        return hash(self.id)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    139
                 | 
                                    
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                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    140
                 | 
                                    
                                                     | 
                
                 | 
                    def __eq__(self, other):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    141
                 | 
                                    
                                                     | 
                
                 | 
                        return self.id == other.id  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    142
                 | 
                                    
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                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    143
                 | 
                                    
                                                     | 
                
                 | 
                    def __lt__(self, other):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    144
                 | 
                                    
                                                     | 
                
                 | 
                        return self.id < other.id  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    145
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                | 
                    146
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                | 
                    147
                 | 
                                    
                                                     | 
                
                 | 
                class Taxonomy:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    148
                 | 
                                    
                                                     | 
                
                 | 
                    """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    149
                 | 
                                    
                                                     | 
                
                 | 
                    A taxonomic tree of organisms from UniProt.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    150
                 | 
                                    
                                                     | 
                
                 | 
                    Elements in the tree can be looked up by name or ID using ``__getitem__`` and ``get``.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    151
                 | 
                                    
                                                     | 
                
                 | 
                    """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    152
                 | 
                                    
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                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    153
                 | 
                                    
                                                     | 
                
                 | 
                    def __init__(self, by_id: Mapping[int, Taxon]):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    154
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    155
                 | 
                                    
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                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    156
                 | 
                                    
                                                     | 
                
                 | 
                        Args:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    157
                 | 
                                    
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                 | 
                            by_id:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    158
                 | 
                                    
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                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    159
                 | 
                                    
                                                     | 
                
                 | 
                        # constructor provided for consistency with the members  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    160
                 | 
                                    
                                                     | 
                
                 | 
                        self._by_id = dict(by_id)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    161
                 | 
                                    
                                                     | 
                
                 | 
                        # this probably isn't actually possible  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    162
                 | 
                                    
                                                     | 
                
                 | 
                        if len(self) == 0:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    163
                 | 
                                    
                                                     | 
                
                 | 
                            logger.warning(f"{self} contains 0 taxa") | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    164
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    165
                 | 
                                    
                                                     | 
                
                 | 
                    @classmethod  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    166
                 | 
                                    
                                                     | 
                
                 | 
                    def from_list(cls, taxa: Sequence[Taxon]) -> Taxonomy:  | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    167
                 | 
                                    
                                                     | 
                
                 | 
                        tax = Taxonomy({x.id: x for x in taxa}) | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    168
                 | 
                                    
                                                     | 
                
                 | 
                        # catch duplicate values  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    169
                 | 
                                    
                                                     | 
                
                 | 
                        assert len(tax._by_id) == len(taxa), f"{len(tax._by_id)} != {len(taxa)}" | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    170
                 | 
                                    
                                                     | 
                
                 | 
                        return tax  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    171
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    172
                 | 
                                    
                                                     | 
                
                 | 
                    @classmethod  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    173
                 | 
                                    
                                                     | 
                
                 | 
                    def from_path(cls, path: Path) -> Taxonomy:  | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    174
                 | 
                                    
                                                     | 
                
                 | 
                        df = pd.read_csv(path, sep="\t", header=0)  | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    175
                 | 
                                    
                                                     | 
                
                 | 
                        return cls.from_df(df)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    176
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    177
                 | 
                                    
                                                     | 
                
                 | 
                    @classmethod  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    178
                 | 
                                    
                                                     | 
                
                 | 
                    def from_df(cls, df: TaxonomyDf) -> Taxonomy:  | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    179
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    180
                 | 
                                    
                                                     | 
                
                 | 
                        Reads from a DataFrame from a CSV file provided by a UniProt download.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    181
                 | 
                                    
                                                     | 
                
                 | 
                        Strips any entries with missing or empty-string scientific names.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    182
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    183
                 | 
                                    
                                                     | 
                
                 | 
                        Args:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    184
                 | 
                                    
                                                     | 
                
                 | 
                            df: A dataframe with columns (at least) "taxon", "scientific_name", and "parent"  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    185
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    186
                 | 
                                    
                                                     | 
                
                 | 
                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    187
                 | 
                                    
                                                     | 
                
                 | 
                            The corresponding taxonomic tree  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    188
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    189
                 | 
                                    
                                                     | 
                
                 | 
                        df["taxon"] = df["taxon"].astype(int)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    190
                 | 
                                    
                                                     | 
                
                 | 
                        # TODO fillna(0) should not be needed  | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    191
                 | 
                                    
                                                     | 
                
                 | 
                        df["parent"] = df["parent"].fillna(0).astype(int)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    192
                 | 
                                    
                                                     | 
                
                 | 
                        # just build up a tree, sticking the elements in by_id  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    193
                 | 
                                    
                                                     | 
                
                 | 
                        tax = {} | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    194
                 | 
                                    
                                                     | 
                
                 | 
                        for row in df.itertuples():  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    195
                 | 
                                    
                                                     | 
                
                 | 
                            child = tax.setdefault(row.taxon, _Taxon(row.taxon, row.scientific_name, None, set()))  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    196
                 | 
                                    
                                                     | 
                
                 | 
                            child.set_name(row.scientific_name)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    197
                 | 
                                    
                                                     | 
                
                 | 
                            if row.parent != 0:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    198
                 | 
                                    
                                                     | 
                
                 | 
                                parent = tax.setdefault(row.parent, _Taxon(row.parent, "", None, set()))  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    199
                 | 
                                    
                                                     | 
                
                 | 
                                child.set_parent(parent)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    200
                 | 
                                    
                                                     | 
                
                 | 
                                parent.add_child(child)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    201
                 | 
                                    
                                                     | 
                
                 | 
                        bad = [t for t in tax.values() if t.name.strip() == ""]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    202
                 | 
                                    
                                                     | 
                
                 | 
                        if len(bad) > 0:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    203
                 | 
                                    
                                                     | 
                
                 | 
                            raise ValueError(f"There are taxa with missing or empty names: {bad}.") | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    204
                 | 
                                    
                                                     | 
                
                 | 
                        for v in tax.values():  | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    205
                 | 
                                    
                                                     | 
                
                 | 
                            v.__class__ = Taxon  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    206
                 | 
                                    
                                                     | 
                
                 | 
                        return Taxonomy(tax)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    207
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    208
                 | 
                                    
                                                     | 
                
                 | 
                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    209
                 | 
                                    
                                                     | 
                
                 | 
                    def taxa(self) -> Sequence[Taxon]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    210
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    211
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    212
                 | 
                                    
                                                     | 
                
                 | 
                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    213
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    214
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    215
                 | 
                                    
                                                     | 
                
                 | 
                        return list(self._by_id.values())  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    216
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    217
                 | 
                                    
                                                     | 
                
                 | 
                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    218
                 | 
                                    
                                                     | 
                
                 | 
                    def roots(self) -> Sequence[Taxon]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    219
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    220
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    221
                 | 
                                    
                                                     | 
                
                 | 
                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    222
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    223
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    224
                 | 
                                    
                                                     | 
                
                 | 
                        return [k for k in self.taxa if k.parent is None or k.parent not in self]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    225
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    226
                 | 
                                    
                                                     | 
                
                 | 
                    @property  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    227
                 | 
                                    
                                                     | 
                
                 | 
                    def leaves(self) -> Sequence[Taxon]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    228
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    229
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    230
                 | 
                                    
                                                     | 
                
                 | 
                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    231
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    232
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    233
                 | 
                                    
                                                     | 
                
                 | 
                        return [k for k in self.taxa if len(k.children) == 0]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    234
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    235
                 | 
                                    
                                                     | 
                
                 | 
                    def subtree(self, item: int) -> Taxonomy:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    236
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    237
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    238
                 | 
                                    
                                                     | 
                
                 | 
                        Args:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    239
                 | 
                                    
                                                     | 
                
                 | 
                            item:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    240
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    241
                 | 
                                    
                                                     | 
                
                 | 
                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    242
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    243
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    244
                 | 
                                    
                                                     | 
                
                 | 
                        item = self[item]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    245
                 | 
                                    
                                                     | 
                
                 | 
                        descendents = {item, *item.descendents} | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    246
                 | 
                                    
                                                     | 
                
                 | 
                        return Taxonomy({d.id: d for d in descendents}) | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    247
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    248
                 | 
                                    
                                                     | 
                
                 | 
                    def req(self, item: int) -> Taxon:  | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    249
                 | 
                                    
                                                     | 
                
                 | 
                        if isinstance(item, Taxon):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    250
                 | 
                                    
                                                     | 
                
                 | 
                            item = item.id  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    251
                 | 
                                    
                                                     | 
                
                 | 
                        return self[item]  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    252
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    253
                 | 
                                    
                                                     | 
                
                 | 
                    def get(self, item: int) -> Optional[Taxon]:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    254
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    255
                 | 
                                    
                                                     | 
                
                 | 
                        Corresponds to ``dict.get``.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    256
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    257
                 | 
                                    
                                                     | 
                
                 | 
                        Args:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    258
                 | 
                                    
                                                     | 
                
                 | 
                            item: The scientific name or UniProt ID  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    259
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    260
                 | 
                                    
                                                     | 
                
                 | 
                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    261
                 | 
                                    
                                                     | 
                
                 | 
                            The taxon, or None if it was not found  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    262
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    263
                 | 
                                    
                                                     | 
                
                 | 
                        if isinstance(item, Taxon):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    264
                 | 
                                    
                                                     | 
                
                 | 
                            item = item.id  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    265
                 | 
                                    
                                                     | 
                
                 | 
                        if isinstance(item, int):  | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    266
                 | 
                                    
                                                     | 
                
                 | 
                            return self._by_id.get(item)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    267
                 | 
                                    
                                                     | 
                
                 | 
                        else:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    268
                 | 
                                    
                                                     | 
                
                 | 
                            raise TypeError(f"Type {type(item)} of {item} not applicable") | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    269
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    270
                 | 
                                    
                                                     | 
                
                 | 
                    def __getitem__(self, item: int) -> Taxon:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    271
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    272
                 | 
                                    
                                                     | 
                
                 | 
                        Corresponds to ``dict[_]``.  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    273
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    274
                 | 
                                    
                                                     | 
                
                 | 
                        Args:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    275
                 | 
                                    
                                                     | 
                
                 | 
                            item: The UniProt ID  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    276
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    277
                 | 
                                    
                                                     | 
                
                 | 
                        Returns:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    278
                 | 
                                    
                                                     | 
                
                 | 
                            The taxon  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    279
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    280
                 | 
                                    
                                                     | 
                
                 | 
                        Raises:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    281
                 | 
                                    
                                                     | 
                
                 | 
                            KeyError: If the taxon was not found  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    282
                 | 
                                    
                                                     | 
                
                 | 
                        """  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    283
                 | 
                                    
                                                     | 
                
                 | 
                        got = self.get(item)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    284
                 | 
                                    
                                                     | 
                
                 | 
                        if got is None:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    285
                 | 
                                    
                                                     | 
                
                 | 
                            raise KeyError(f"{item} not found in {self}") | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    286
                 | 
                                    
                                                     | 
                
                 | 
                        return got  | 
            
            
                                                                                                            
                                                                
            
                                    
            
            
                | 
                    287
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                        
                            
            
                                    
            
            
                | 
                    288
                 | 
                                    
                                                     | 
                
                 | 
                    def contains(self, item: Union[Taxon, int, str]):  | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                        
                            
            
                                    
            
            
                | 
                    289
                 | 
                                    
                                                     | 
                
                 | 
                        return self.get(item) is not None  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    290
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    291
                 | 
                                    
                                                     | 
                
                 | 
                    def n_taxa(self) -> int:  | 
            
                            
                    | 
                        
                     | 
                     | 
                     | 
                    
                                                                                                    
                        
                         
                                                                                        
                                                                                     
                     | 
                
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    292
                 | 
                                    
                                                     | 
                
                 | 
                        return len(self._by_id)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    293
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    294
                 | 
                                    
                                                     | 
                
                 | 
                    def __contains__(self, item: Union[Taxon, int, str]):  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    295
                 | 
                                    
                                                     | 
                
                 | 
                        return self.get(item) is not None  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    296
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    297
                 | 
                                    
                                                     | 
                
                 | 
                    def __len__(self) -> int:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    298
                 | 
                                    
                                                     | 
                
                 | 
                        return len(self._by_id)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    299
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    300
                 | 
                                    
                                                     | 
                
                 | 
                    def __str__(self) -> str:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    301
                 | 
                                    
                                                     | 
                
                 | 
                        return repr(self)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    302
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    303
                 | 
                                    
                                                     | 
                
                 | 
                    def __repr__(self) -> str:  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    304
                 | 
                                    
                                                     | 
                
                 | 
                        roots = ", ".join(r.name for r in self.roots)  | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    305
                 | 
                                    
                                                     | 
                
                 | 
                        return f"{self.__class__.__name__}(n={len(self._by_id)} (roots={roots}) @ {hex(id(self))})" | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    306
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                            
            
                                    
            
            
                | 
                    307
                 | 
                                    
                                                     | 
                
                 | 
                 | 
            
            
                                                                                                            
                                                                
            
                                    
            
            
                | 
                    308
                 | 
                                    
                                                     | 
                
                 | 
                __all__ = ["Taxon", "Taxonomy"]  | 
            
            
                                                        
            
                                    
            
            
                | 
                    309
                 | 
                                    
                                                     | 
                
                 | 
                 |