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import logging |
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import os |
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import shlex |
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from django.contrib.auth.models import User |
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from django.contrib.contenttypes.fields import GenericRelation |
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from django.db import models |
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from django.db.models import Func, Value, F |
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from django.db.models.signals import post_save |
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from django.dispatch import receiver |
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from django.urls import reverse |
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from common.fields import ProtectedFileField |
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from common.constants import ( |
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OBO_URL, STATUSES, CONFIDENCES, NAME_STATUSES, ACCURACIES, WAITING, LOADED, |
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MISSING, DATA_TYPES, TIME_UNITS, SAMPLE_STORAGE, SAMPLE_STORAGE_PROCESSING, |
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READY) |
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from common.helpers import format_attribute |
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from .mixins import BaseMixin, BioSampleMixin |
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# Get an instance of a logger |
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logger = logging.getLogger(__name__) |
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class Replace(Func): |
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function = 'REPLACE' |
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# --- Abstract classes |
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# helper classes |
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class DictBase(BaseMixin, models.Model): |
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""" |
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Abstract class to be inherited to all dictionary tables. It models fields |
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like ``label`` (the revised term like submitter or blood) and |
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``term`` (the ontology id as the final part of the URI link) |
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The fixed part of the URI could be customized from :py:class:`Ontology` |
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by setting ``library_name`` class attribute accordingly:: |
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class DictRole(DictBase): |
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library_name = 'EFO' |
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""" |
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library_name = None |
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# if not defined, this table will have an own primary key |
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label = models.CharField( |
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max_length=255, |
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blank=False, |
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help_text="Example: submitter") |
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term = models.CharField( |
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max_length=255, |
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blank=False, |
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null=True, |
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help_text="Example: EFO_0001741") |
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class Meta: |
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# Abstract base classes are useful when you want to put some common |
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# information into a number of other models |
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abstract = True |
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def __str__(self): |
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return "{label} ({term})".format( |
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label=self.label, |
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term=self.term) |
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def format_attribute(self): |
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""" |
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Format an object instance as a dictionary used by biosample, for |
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example:: |
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[{ |
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'value': 'submitter', |
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'terms': [{'url': 'http://www.ebi.ac.uk/efo/EFO_0001741'}] |
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}] |
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the fixed part of URI link is defined by ``library_name`` class |
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attribute |
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""" |
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if self.library_name is None: |
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logger.warning("library_name not defined") |
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library_uri = OBO_URL |
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else: |
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library = Ontology.objects.get(library_name=self.library_name) |
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library_uri = library.library_uri |
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return format_attribute( |
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value=self.label, |
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library_uri=library_uri, |
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terms=self.term) |
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class Confidence(BaseMixin, models.Model): |
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""" |
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Abstract class which add :ref:`confidence <Common confidences>` |
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to models |
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""" |
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# confidence field (enum) |
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confidence = models.SmallIntegerField( |
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choices=[x.value for x in CONFIDENCES], |
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help_text='example: Manually Curated', |
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null=True) |
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class Meta: |
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# Abstract base classes are useful when you want to put some common |
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# information into a number of other models |
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abstract = True |
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class Name(BaseMixin, models.Model): |
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"""Model UID names: define a name (sample or animal) unique for each |
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data submission""" |
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__validationresult = None |
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# two different animal may have the same name. Its unicity depens on |
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# data source name and version |
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name = models.CharField( |
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max_length=255, |
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blank=False, |
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null=False) |
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submission = models.ForeignKey( |
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'Submission', |
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related_name='%(class)s_set', |
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on_delete=models.CASCADE) |
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# This will be assigned after submission |
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biosample_id = models.CharField( |
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max_length=255, |
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blank=True, |
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null=True, |
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unique=True) |
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# '+' instructs Django that we don’t need this reverse relationship |
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owner = models.ForeignKey( |
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User, |
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related_name='+', |
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on_delete=models.CASCADE) |
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# a column to track submission status |
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status = models.SmallIntegerField( |
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choices=[x.value for x in STATUSES if x.name in NAME_STATUSES], |
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help_text='example: Submitted', |
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default=LOADED) |
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last_changed = models.DateTimeField( |
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auto_now_add=True, |
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blank=True, |
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null=True) |
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last_submitted = models.DateTimeField( |
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blank=True, |
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null=True) |
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publication = models.ForeignKey( |
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'Publication', |
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null=True, |
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blank=True, |
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on_delete=models.SET_NULL) |
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# alternative id will store the internal id in data source |
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alternative_id = models.CharField( |
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max_length=255) |
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description = models.CharField( |
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max_length=255, |
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blank=True, |
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null=True) |
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validationresults = GenericRelation( |
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'validation.ValidationResult', |
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related_query_name='%(class)ss') |
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# https://www.machinelearningplus.com/python/python-property/ |
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# https://stackoverflow.com/questions/7837330/generic-one-to-one-relation-in-django |
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@property |
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def validationresult(self): |
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"""return the first validationresult object (should be uinique)""" |
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if not self.__validationresult: |
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self.__validationresult = self.validationresults.first() |
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return self.__validationresult |
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@validationresult.setter |
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def validationresult(self, validationresult): |
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"""return the first validationresult object (should be uinique)""" |
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# destroying relathionship when passin a None object |
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if not validationresult: |
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del(self.validationresult) |
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else: |
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# bind object to self |
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validationresult.submission = self.submission |
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validationresult.content_object = self |
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validationresult.save() |
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# update cache (object already bound with save) |
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self.__validationresult = validationresult |
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@validationresult.deleter |
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def validationresult(self): |
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"""return the first validationresult object (should be uinique)""" |
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if not self.__validationresult: |
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self.__validationresult = self.validationresults.first() |
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# for a genericrelation, removin an object mean destroy it |
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self.validationresults.remove(self.__validationresult) |
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self.__validationresult = None |
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class Meta: |
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# Abstract base classes are useful when you want to put some common |
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# information into a number of other models |
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abstract = True |
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# --- dictionary tables |
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class DictRole(DictBase): |
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"""A class to model roles defined as childs of |
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http://www.ebi.ac.uk/efo/EFO_0002012""" |
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library_name = 'EFO' |
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class Meta: |
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# db_table will be <app_name>_<classname> |
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verbose_name = "role" |
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unique_together = (("label", "term"),) |
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class DictCountry(DictBase, Confidence): |
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"""A class to model contries defined by NCI Thesaurus OBO Edition |
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https://www.ebi.ac.uk/ols/ontologies/ncit""" |
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library_name = 'NCIT' |
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class Meta: |
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# db_table will be <app_name>_<classname> |
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verbose_name = "country" |
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verbose_name_plural = "countries" |
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unique_together = (("label", "term"),) |
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ordering = ['label'] |
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class DictSex(DictBase): |
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"""A class to model sex as defined in PATO""" |
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library_name = "PATO" |
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class Meta: |
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verbose_name = 'sex' |
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verbose_name_plural = 'sex' |
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unique_together = (("label", "term"),) |
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class DictUberon(DictBase, Confidence): |
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"""A class to model anatomies modeled in uberon""" |
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library_name = "UBERON" |
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class Meta: |
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verbose_name = 'organism part' |
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unique_together = (("label", "term"),) |
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class DictDevelStage(DictBase, Confidence): |
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"""A class to developmental stages defined as descendants of |
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descendants of EFO_0000399""" |
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library_name = 'EFO' |
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class Meta: |
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# db_table will be <app_name>_<classname> |
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verbose_name = "developmental stage" |
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unique_together = (("label", "term"),) |
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class DictPhysioStage(DictBase, Confidence): |
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"""A class to physiological stages defined as descendants of |
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descendants of PATO_0000261""" |
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library_name = 'PATO' |
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class Meta: |
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# db_table will be <app_name>_<classname> |
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verbose_name = "physiological stage" |
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unique_together = (("label", "term"),) |
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class DictSpecie(DictBase, Confidence): |
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"""A class to model species defined by NCBI organismal classification |
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http://www.ebi.ac.uk/ols/ontologies/ncbitaxon""" |
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library_name = "NCBITaxon" |
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# set general breed to dictspecie objects |
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general_breed_label = models.CharField( |
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max_length=255, |
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blank=True, |
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null=True, |
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help_text="Example: cattle breed", |
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verbose_name="general breed label") |
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general_breed_term = models.CharField( |
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max_length=255, |
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blank=True, |
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null=True, |
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help_text="Example: LBO_0000001", |
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verbose_name="general breed term") |
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@property |
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def taxon_id(self): |
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if not self.term or self.term == '': |
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return None |
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return int(self.term.split("_")[-1]) |
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class Meta: |
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# db_table will be <app_name>_<classname> |
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verbose_name = "specie" |
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unique_together = (("label", "term"),) |
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@classmethod |
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def get_by_synonym(cls, synonym, language): |
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"""return an instance by synonym in supplied language or default one""" |
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# get a queryset with speciesynonym |
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qs = cls.objects.prefetch_related('speciesynonym_set') |
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# annotate queryset by removing spaces from speciesynonym word |
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qs = qs.annotate( |
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new_word=Replace('speciesynonym__word', Value(" "), Value("")), |
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language=F('speciesynonym__language__label')) |
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# now remove spaces from synonym |
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synonym = synonym.replace(" ", "") |
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try: |
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specie = qs.get( |
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new_word=synonym, |
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language=language) |
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except cls.DoesNotExist: |
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specie = qs.get( |
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new_word=synonym, |
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language="United Kingdom") |
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return specie |
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@classmethod |
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def get_specie_check_synonyms(cls, species_label, language): |
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"""get a DictSpecie object. Species are in latin names, but I can |
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find also a common name in translation tables""" |
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try: |
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specie = cls.objects.get(label=species_label) |
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except cls.DoesNotExist: |
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logger.info("Search %s in %s synonyms" % (species_label, language)) |
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# search for language synonym (if I arrived here a synonym should |
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# exists) |
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specie = cls.get_by_synonym( |
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synonym=species_label, |
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language=language) |
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return specie |
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class DictBreed(Confidence): |
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"""A class to deal with breed objects and their ontologies""" |
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|
|
|
384
|
|
|
library_name = "LBO" |
385
|
|
|
|
386
|
|
|
# this was the description field in cryoweb v_breeds_species tables |
387
|
|
|
supplied_breed = models.CharField(max_length=255, blank=False) |
388
|
|
|
|
389
|
|
|
# those can't be null like other DictBase classes |
390
|
|
|
# HINT: if every breed should have a mapped breed referring a specie |
391
|
|
|
# at least, could I inherit from DictBase class? |
392
|
|
|
label = models.CharField( |
393
|
|
|
max_length=255, |
394
|
|
|
blank=False, |
395
|
|
|
null=True, |
396
|
|
|
verbose_name="mapped breed") |
397
|
|
|
|
398
|
|
|
# old mapped_breed_term |
399
|
|
|
term = models.CharField( |
400
|
|
|
max_length=255, |
401
|
|
|
blank=False, |
402
|
|
|
null=True, |
403
|
|
|
help_text="Example: LBO_0000347", |
404
|
|
|
verbose_name="mapped breed term") |
405
|
|
|
|
406
|
|
|
# using a constraint for country. |
407
|
|
|
country = models.ForeignKey( |
408
|
|
|
'DictCountry', |
409
|
|
|
on_delete=models.PROTECT) |
410
|
|
|
|
411
|
|
|
# using a constraint for specie |
412
|
|
|
specie = models.ForeignKey( |
413
|
|
|
'DictSpecie', |
414
|
|
|
on_delete=models.PROTECT) |
415
|
|
|
|
416
|
|
|
class Meta: |
417
|
|
|
verbose_name = 'breed' |
418
|
|
|
unique_together = (("supplied_breed", "specie", "country"),) |
419
|
|
|
|
420
|
|
|
def __str__(self): |
421
|
|
|
return "{supplied} - {country} ({mapped}, {specie})".format( |
422
|
|
|
country=self.country.label, |
423
|
|
|
supplied=self.supplied_breed, |
424
|
|
|
mapped=self.mapped_breed, |
425
|
|
|
specie=self.specie.label) |
426
|
|
|
|
427
|
|
|
@property |
428
|
|
|
def mapped_breed(self): |
429
|
|
|
"""Alias for label attribute. Return general label if no term is |
430
|
|
|
found""" |
431
|
|
|
|
432
|
|
|
if self.label and self.label != '': |
433
|
|
|
return self.label |
434
|
|
|
|
435
|
|
|
elif (self.specie.general_breed_label and |
436
|
|
|
self.specie.general_breed_label != ''): |
437
|
|
|
return self.specie.general_breed_label |
438
|
|
|
|
439
|
|
|
else: |
440
|
|
|
return None |
441
|
|
|
|
442
|
|
|
@mapped_breed.setter |
443
|
|
|
def mapped_breed(self, label): |
444
|
|
|
"""Alias for label attribute""" |
445
|
|
|
|
446
|
|
|
self.label = label |
447
|
|
|
|
448
|
|
|
@property |
449
|
|
|
def mapped_breed_term(self): |
450
|
|
|
"""Alias for term attribute. Return general term if no term is found""" |
451
|
|
|
|
452
|
|
|
if self.term and self.term != '': |
453
|
|
|
return self.term |
454
|
|
|
|
455
|
|
|
elif (self.specie.general_breed_term and |
456
|
|
|
self.specie.general_breed_term != ''): |
457
|
|
|
return self.specie.general_breed_term |
458
|
|
|
|
459
|
|
|
else: |
460
|
|
|
return None |
461
|
|
|
|
462
|
|
|
@mapped_breed_term.setter |
463
|
|
|
def mapped_breed_term(self, term): |
464
|
|
|
"""Alias for label attribute""" |
465
|
|
|
|
466
|
|
|
self.term = term |
467
|
|
|
|
468
|
|
|
def format_attribute(self): |
469
|
|
|
"""Format mapped_breed attribute (with its ontology). Return None if |
470
|
|
|
no mapped_breed""" |
471
|
|
|
|
472
|
|
|
if not self.mapped_breed or not self.mapped_breed_term: |
473
|
|
|
return None |
474
|
|
|
|
475
|
|
|
library = Ontology.objects.get(library_name=self.library_name) |
476
|
|
|
library_uri = library.library_uri |
477
|
|
|
|
478
|
|
|
return format_attribute( |
479
|
|
|
value=self.mapped_breed, |
480
|
|
|
library_uri=library_uri, |
481
|
|
|
terms=self.mapped_breed_term) |
482
|
|
|
|
483
|
|
|
|
484
|
|
|
# --- Other tables tables |
485
|
|
|
|
486
|
|
|
|
487
|
|
|
class Animal(BioSampleMixin, Name): |
488
|
|
|
""" |
489
|
|
|
Class to model Animal (Organism). Inherits from :py:class:`BioSampleMixin`, |
490
|
|
|
related to :py:class:`Name` through ``OneToOne`` relationship to model |
491
|
|
|
Animal name (Data source id), and with the same relationship to model |
492
|
|
|
``mother`` and ``father`` of such animal. In case that parents are unknown, |
493
|
|
|
could be linked with Unkwnon animals for cryoweb data or doens't have |
494
|
|
|
relationship.Linked to :py:class:`DictBreed` dictionary |
495
|
|
|
table to model info on species and breed. Linked to |
496
|
|
|
:py:class:`Sample` to model Samples (Specimen from organims):: |
497
|
|
|
|
498
|
|
|
from uid.models import Animal |
499
|
|
|
|
500
|
|
|
# get animal using primary key |
501
|
|
|
animal = Animal.objects.get(pk=1) |
502
|
|
|
|
503
|
|
|
# get animal name |
504
|
|
|
data_source_id = animal.name |
505
|
|
|
|
506
|
|
|
# get animal's parents |
507
|
|
|
mother = animal.mother |
508
|
|
|
father = animal.father |
509
|
|
|
|
510
|
|
|
# get breed and species info |
511
|
|
|
print(animal.breed.supplied_breed) |
512
|
|
|
print(animal.breed.specie.label) |
513
|
|
|
|
514
|
|
|
# get all samples (specimen) for this animals |
515
|
|
|
samples = animal.sample_set.all() |
516
|
|
|
""" |
517
|
|
|
|
518
|
|
|
material = models.CharField( |
519
|
|
|
max_length=255, |
520
|
|
|
default="Organism", |
521
|
|
|
editable=False) |
522
|
|
|
|
523
|
|
|
breed = models.ForeignKey( |
524
|
|
|
'DictBreed', |
525
|
|
|
db_index=True, |
526
|
|
|
on_delete=models.PROTECT) |
527
|
|
|
|
528
|
|
|
# species is in DictBreed table |
529
|
|
|
|
530
|
|
|
# using a constraint for sex |
531
|
|
|
sex = models.ForeignKey( |
532
|
|
|
'DictSex', |
533
|
|
|
on_delete=models.PROTECT) |
534
|
|
|
|
535
|
|
|
# check that father and mother are defined using Foreign Keys |
536
|
|
|
# HINT: mother and father are not mandatory in all datasource |
537
|
|
|
father = models.ForeignKey( |
538
|
|
|
'self', |
539
|
|
|
on_delete=models.CASCADE, |
540
|
|
|
null=True, |
541
|
|
|
related_name='father_of') |
542
|
|
|
|
543
|
|
|
mother = models.ForeignKey( |
544
|
|
|
'self', |
545
|
|
|
on_delete=models.CASCADE, |
546
|
|
|
null=True, |
547
|
|
|
related_name='mother_of') |
548
|
|
|
|
549
|
|
|
birth_date = models.DateField( |
550
|
|
|
blank=True, |
551
|
|
|
null=True, |
552
|
|
|
help_text='example: 2019-04-01') |
553
|
|
|
|
554
|
|
|
birth_location = models.CharField( |
555
|
|
|
max_length=255, |
556
|
|
|
blank=True, |
557
|
|
|
null=True) |
558
|
|
|
|
559
|
|
|
birth_location_latitude = models.FloatField(blank=True, null=True) |
560
|
|
|
birth_location_longitude = models.FloatField(blank=True, null=True) |
561
|
|
|
|
562
|
|
|
# accuracy field (enum) |
563
|
|
|
birth_location_accuracy = models.SmallIntegerField( |
564
|
|
|
choices=[x.value for x in ACCURACIES], |
565
|
|
|
help_text='example: unknown accuracy level, country level', |
566
|
|
|
null=False, |
567
|
|
|
blank=False, |
568
|
|
|
default=MISSING) |
569
|
|
|
|
570
|
|
|
class Meta: |
571
|
|
|
unique_together = (("name", "breed", "owner"),) |
572
|
|
|
|
573
|
|
|
@property |
574
|
|
|
def specie(self): |
575
|
|
|
return self.breed.specie |
576
|
|
|
|
577
|
|
|
@property |
578
|
|
|
def biosample_alias(self): |
579
|
|
|
return 'IMAGEA{0:09d}'.format(self.id) |
580
|
|
|
|
581
|
|
|
def get_attributes(self): |
582
|
|
|
"""Return attributes like biosample needs""" |
583
|
|
|
|
584
|
|
|
attributes = super().get_attributes() |
585
|
|
|
|
586
|
|
|
attributes["Material"] = format_attribute( |
587
|
|
|
value="organism", terms="OBI_0100026") |
588
|
|
|
|
589
|
|
|
# TODO: how to model derived from (mother/father)? |
590
|
|
|
|
591
|
|
|
attributes['Supplied breed'] = format_attribute( |
592
|
|
|
value=self.breed.supplied_breed) |
593
|
|
|
|
594
|
|
|
# HINT: Ideally, I could retrieve an ontology id for countries |
595
|
|
|
attributes['EFABIS Breed country'] = format_attribute( |
596
|
|
|
value=self.breed.country.label) |
597
|
|
|
|
598
|
|
|
attributes['Mapped breed'] = self.breed.format_attribute() |
599
|
|
|
|
600
|
|
|
attributes['Sex'] = self.sex.format_attribute() |
601
|
|
|
|
602
|
|
|
# a datetime object should be not be converted in string here, |
603
|
|
|
# otherwise will not be filtered if NULL |
604
|
|
|
attributes['Birth date'] = format_attribute( |
605
|
|
|
value=self.birth_date, units="YYYY-MM-DD") |
606
|
|
|
|
607
|
|
|
attributes["Birth location"] = format_attribute( |
608
|
|
|
value=self.birth_location) |
609
|
|
|
|
610
|
|
|
attributes["Birth location longitude"] = format_attribute( |
611
|
|
|
value=self.birth_location_longitude, |
612
|
|
|
units="decimal degrees") |
613
|
|
|
|
614
|
|
|
attributes["Birth location latitude"] = format_attribute( |
615
|
|
|
value=self.birth_location_latitude, |
616
|
|
|
units="decimal degrees") |
617
|
|
|
|
618
|
|
|
attributes["Birth location accuracy"] = format_attribute( |
619
|
|
|
value=self.get_birth_location_accuracy_display()) |
620
|
|
|
|
621
|
|
|
# filter out empty values |
622
|
|
|
attributes = {k: v for k, v in attributes.items() if v is not None} |
623
|
|
|
|
624
|
|
|
return attributes |
625
|
|
|
|
626
|
|
|
def get_relationship(self, nature="derived from"): |
627
|
|
|
"""Get a relationship to this animal (call this method from a related |
628
|
|
|
object to get a connection to this element) |
629
|
|
|
|
630
|
|
|
Args: |
631
|
|
|
nature (str): set relationship nature (child of, derived_from, ...) |
632
|
|
|
""" |
633
|
|
|
|
634
|
|
|
# if animal is already uploaded I will use accession as |
635
|
|
|
# relationship key. This biosample id could be tested in validation |
636
|
|
|
if self.biosample_id and self.biosample_id != '': |
637
|
|
|
return { |
638
|
|
|
"accession": self.biosample_id, |
639
|
|
|
"relationshipNature": nature, |
640
|
|
|
} |
641
|
|
|
else: |
642
|
|
|
return { |
643
|
|
|
"alias": self.biosample_alias, |
644
|
|
|
"relationshipNature": nature, |
645
|
|
|
} |
646
|
|
|
|
647
|
|
|
def get_father_relationship(self): |
648
|
|
|
"""Get a relationship with father if possible""" |
649
|
|
|
|
650
|
|
|
# get father of this animal |
651
|
|
|
if self.father is None: |
652
|
|
|
return None |
653
|
|
|
|
654
|
|
|
return self.father.get_relationship(nature="child of") |
655
|
|
|
|
656
|
|
|
def get_mother_relationship(self): |
657
|
|
|
"""Get a relationship with mother if possible""" |
658
|
|
|
|
659
|
|
|
# get mother of this animal |
660
|
|
|
if self.mother is None: |
661
|
|
|
return None |
662
|
|
|
|
663
|
|
|
return self.mother.get_relationship(nature="child of") |
664
|
|
|
|
665
|
|
|
def to_biosample(self, release_date=None): |
666
|
|
|
"""get a json from animal for biosample submission""" |
667
|
|
|
|
668
|
|
|
# call methods defined in BioSampleMixin and get result |
669
|
|
|
# with USI mandatory keys and attributes |
670
|
|
|
result = super().to_biosample(release_date) |
671
|
|
|
|
672
|
|
|
# define relationship with mother and father (if possible) |
673
|
|
|
result['sampleRelationships'] = [] |
674
|
|
|
|
675
|
|
|
father_relationship = self.get_father_relationship() |
676
|
|
|
|
677
|
|
|
if father_relationship is not None: |
678
|
|
|
result['sampleRelationships'].append(father_relationship) |
679
|
|
|
|
680
|
|
|
mother_relationship = self.get_mother_relationship() |
681
|
|
|
|
682
|
|
|
if mother_relationship is not None: |
683
|
|
|
result['sampleRelationships'].append(mother_relationship) |
684
|
|
|
|
685
|
|
|
return result |
686
|
|
|
|
687
|
|
|
def get_absolute_url(self): |
688
|
|
|
return reverse("animals:detail", kwargs={"pk": self.pk}) |
689
|
|
|
|
690
|
|
|
|
691
|
|
|
class Sample(BioSampleMixin, Name): |
692
|
|
|
material = models.CharField( |
693
|
|
|
max_length=255, |
694
|
|
|
default="Specimen from Organism", |
695
|
|
|
editable=False) |
696
|
|
|
|
697
|
|
|
animal = models.ForeignKey( |
698
|
|
|
'Animal', |
699
|
|
|
on_delete=models.CASCADE) |
700
|
|
|
|
701
|
|
|
# HINT: should this be a protocol? |
702
|
|
|
protocol = models.CharField( |
703
|
|
|
max_length=255, |
704
|
|
|
blank=True, |
705
|
|
|
null=True) |
706
|
|
|
|
707
|
|
|
collection_date = models.DateField( |
708
|
|
|
blank=True, |
709
|
|
|
null=True, |
710
|
|
|
help_text='example: 2019-04-01') |
711
|
|
|
|
712
|
|
|
collection_place_latitude = models.FloatField(blank=True, null=True) |
713
|
|
|
collection_place_longitude = models.FloatField(blank=True, null=True) |
714
|
|
|
collection_place = models.CharField(max_length=255, blank=True, null=True) |
715
|
|
|
|
716
|
|
|
# accuracy field (enum) |
717
|
|
|
collection_place_accuracy = models.SmallIntegerField( |
718
|
|
|
choices=[x.value for x in ACCURACIES], |
719
|
|
|
help_text='example: unknown accuracy level, country level', |
720
|
|
|
null=False, |
721
|
|
|
blank=False, |
722
|
|
|
default=MISSING) |
723
|
|
|
|
724
|
|
|
# using a constraint for organism (DictUberon) |
725
|
|
|
organism_part = models.ForeignKey( |
726
|
|
|
'DictUberon', |
727
|
|
|
on_delete=models.PROTECT) |
728
|
|
|
|
729
|
|
|
# using a constraint for developmental stage (DictDevelStage) |
730
|
|
|
developmental_stage = models.ForeignKey( |
731
|
|
|
'DictDevelStage', |
732
|
|
|
null=True, |
733
|
|
|
blank=True, |
734
|
|
|
on_delete=models.PROTECT) |
735
|
|
|
|
736
|
|
|
physiological_stage = models.ForeignKey( |
737
|
|
|
'DictPhysioStage', |
738
|
|
|
null=True, |
739
|
|
|
blank=True, |
740
|
|
|
on_delete=models.PROTECT) |
741
|
|
|
|
742
|
|
|
animal_age_at_collection = models.IntegerField( |
743
|
|
|
null=True, |
744
|
|
|
blank=True) |
745
|
|
|
|
746
|
|
|
animal_age_at_collection_units = models.SmallIntegerField( |
747
|
|
|
choices=[x.value for x in TIME_UNITS], |
748
|
|
|
help_text='example: years', |
749
|
|
|
null=True, |
750
|
|
|
blank=True) |
751
|
|
|
|
752
|
|
|
availability = models.CharField( |
753
|
|
|
max_length=255, |
754
|
|
|
blank=True, |
755
|
|
|
null=True, |
756
|
|
|
help_text=( |
757
|
|
|
"Either a link to a web page giving information on who to contact " |
758
|
|
|
"or an e-mail address to contact about availability. If neither " |
759
|
|
|
"available, please use the value no longer available") |
760
|
|
|
) |
761
|
|
|
|
762
|
|
|
storage = models.SmallIntegerField( |
763
|
|
|
choices=[x.value for x in SAMPLE_STORAGE], |
764
|
|
|
help_text='How the sample was stored', |
765
|
|
|
null=True, |
766
|
|
|
blank=True) |
767
|
|
|
|
768
|
|
|
storage_processing = models.SmallIntegerField( |
769
|
|
|
choices=[x.value for x in SAMPLE_STORAGE_PROCESSING], |
770
|
|
|
help_text='How the sample was prepared for storage', |
771
|
|
|
null=True, |
772
|
|
|
blank=True) |
773
|
|
|
|
774
|
|
|
preparation_interval = models.IntegerField( |
775
|
|
|
blank=True, |
776
|
|
|
null=True) |
777
|
|
|
|
778
|
|
|
preparation_interval_units = models.SmallIntegerField( |
779
|
|
|
choices=[x.value for x in TIME_UNITS], |
780
|
|
|
help_text='example: years', |
781
|
|
|
null=True, |
782
|
|
|
blank=True) |
783
|
|
|
|
784
|
|
|
class Meta: |
785
|
|
|
unique_together = (("name", "animal", "owner"),) |
786
|
|
|
|
787
|
|
|
@property |
788
|
|
|
def specie(self): |
789
|
|
|
return self.animal.breed.specie |
790
|
|
|
|
791
|
|
|
@property |
792
|
|
|
def biosample_alias(self): |
793
|
|
|
return 'IMAGES{0:09d}'.format(self.id) |
794
|
|
|
|
795
|
|
|
def get_attributes(self): |
796
|
|
|
"""Return attributes like biosample needs""" |
797
|
|
|
|
798
|
|
|
attributes = super().get_attributes() |
799
|
|
|
|
800
|
|
|
attributes["Material"] = format_attribute( |
801
|
|
|
value="specimen from organism", terms="OBI_0001479") |
802
|
|
|
|
803
|
|
|
# The data source id or alternative id of the animal from which |
804
|
|
|
# the sample was collected (see Animal.to_biosample()) |
805
|
|
|
attributes['Derived from'] = format_attribute( |
806
|
|
|
value=self.animal.name) |
807
|
|
|
|
808
|
|
|
attributes["Specimen collection protocol"] = format_attribute( |
809
|
|
|
value=self.protocol) |
810
|
|
|
|
811
|
|
|
# a datetime object should be not be converted in string here, |
812
|
|
|
# otherwise will not be filtered if NULL |
813
|
|
|
attributes['Collection date'] = format_attribute( |
814
|
|
|
value=self.collection_date, units="YYYY-MM-DD") |
815
|
|
|
|
816
|
|
|
attributes['Collection place'] = format_attribute( |
817
|
|
|
value=self.collection_place) |
818
|
|
|
|
819
|
|
|
attributes["Collection place longitude"] = format_attribute( |
820
|
|
|
value=self.collection_place_longitude, |
821
|
|
|
units="decimal degrees") |
822
|
|
|
|
823
|
|
|
attributes["Collection place latitude"] = format_attribute( |
824
|
|
|
value=self.collection_place_latitude, |
825
|
|
|
units="decimal degrees") |
826
|
|
|
|
827
|
|
|
attributes["Collection place accuracy"] = format_attribute( |
828
|
|
|
value=self.get_collection_place_accuracy_display()) |
829
|
|
|
|
830
|
|
|
# this will point to a correct term dictionary table |
831
|
|
|
if self.organism_part: |
832
|
|
|
attributes['Organism part'] = self.organism_part.format_attribute() |
833
|
|
|
|
834
|
|
|
if self.developmental_stage: |
835
|
|
|
attributes['Developmental stage'] = \ |
836
|
|
|
self.developmental_stage.format_attribute() |
837
|
|
|
|
838
|
|
|
if self.physiological_stage: |
839
|
|
|
attributes['Physiological stage'] = \ |
840
|
|
|
self.physiological_stage.format_attribute() |
841
|
|
|
|
842
|
|
|
attributes['Animal age at collection'] = format_attribute( |
843
|
|
|
value=self.animal_age_at_collection, |
844
|
|
|
units=self.get_animal_age_at_collection_units_display()) |
845
|
|
|
|
846
|
|
|
attributes['Availability'] = format_attribute( |
847
|
|
|
value=self.availability) |
848
|
|
|
|
849
|
|
|
attributes['Sample storage'] = format_attribute( |
850
|
|
|
value=self.get_storage_display()) |
851
|
|
|
|
852
|
|
|
attributes['Sample storage processing'] = format_attribute( |
853
|
|
|
value=self.get_storage_processing_display()) |
854
|
|
|
|
855
|
|
|
attributes['Sampling to preparation interval'] = format_attribute( |
856
|
|
|
value=self.preparation_interval, |
857
|
|
|
units=self.get_preparation_interval_units_display()) |
858
|
|
|
|
859
|
|
|
# filter out empty values |
860
|
|
|
attributes = {k: v for k, v in attributes.items() if v is not None} |
861
|
|
|
|
862
|
|
|
return attributes |
863
|
|
|
|
864
|
|
|
def to_biosample(self, release_date=None): |
865
|
|
|
"""get a json from sample for biosample submission""" |
866
|
|
|
|
867
|
|
|
# call methods defined in BioSampleMixin and get result |
868
|
|
|
# with USI mandatory keys and attributes |
869
|
|
|
result = super().to_biosample(release_date) |
870
|
|
|
|
871
|
|
|
# define relationship to the animal where this sample come from |
872
|
|
|
result['sampleRelationships'] = [self.animal.get_relationship()] |
873
|
|
|
|
874
|
|
|
return result |
875
|
|
|
|
876
|
|
|
def get_absolute_url(self): |
877
|
|
|
return reverse("samples:detail", kwargs={"pk": self.pk}) |
878
|
|
|
|
879
|
|
|
|
880
|
|
|
class Person(BaseMixin, models.Model): |
881
|
|
|
user = models.OneToOneField( |
882
|
|
|
User, |
883
|
|
|
on_delete=models.CASCADE, |
884
|
|
|
related_name='person') |
885
|
|
|
|
886
|
|
|
initials = models.CharField(max_length=255, blank=True, null=True) |
887
|
|
|
|
888
|
|
|
# HINT: with a OneToOneField relation, there will be only one user for |
889
|
|
|
# each organization |
890
|
|
|
affiliation = models.ForeignKey( |
891
|
|
|
'Organization', |
892
|
|
|
null=True, |
893
|
|
|
on_delete=models.PROTECT, |
894
|
|
|
help_text="The institution you belong to") |
895
|
|
|
|
896
|
|
|
# last_name, first_name and email come from User model |
897
|
|
|
|
898
|
|
|
role = models.ForeignKey( |
899
|
|
|
'DictRole', |
900
|
|
|
on_delete=models.PROTECT, |
901
|
|
|
null=True) |
902
|
|
|
|
903
|
|
|
def __str__(self): |
904
|
|
|
return "{name} {surname} ({affiliation})".format( |
905
|
|
|
name=self.user.first_name, |
906
|
|
|
surname=self.user.last_name, |
907
|
|
|
affiliation=self.affiliation) |
908
|
|
|
|
909
|
|
|
|
910
|
|
|
class Organization(BaseMixin, models.Model): |
911
|
|
|
# id = models.IntegerField(primary_key=True) # AutoField? |
912
|
|
|
name = models.CharField(max_length=255) |
913
|
|
|
|
914
|
|
|
address = models.CharField( |
915
|
|
|
max_length=255, blank=True, null=True, |
916
|
|
|
help_text='One line, comma separated') |
917
|
|
|
|
918
|
|
|
country = models.ForeignKey( |
919
|
|
|
'DictCountry', |
920
|
|
|
on_delete=models.PROTECT) |
921
|
|
|
|
922
|
|
|
URI = models.URLField( |
923
|
|
|
max_length=500, blank=True, null=True, |
924
|
|
|
help_text='Web site') |
925
|
|
|
|
926
|
|
|
role = models.ForeignKey( |
927
|
|
|
'DictRole', |
928
|
|
|
on_delete=models.PROTECT) |
929
|
|
|
|
930
|
|
|
def __str__(self): |
931
|
|
|
return "%s (%s)" % (self.name, self.country.label) |
932
|
|
|
|
933
|
|
|
class Meta: |
934
|
|
|
ordering = ['name', 'country'] |
935
|
|
|
|
936
|
|
|
|
937
|
|
|
class Publication(BaseMixin, models.Model): |
938
|
|
|
# this is a non mandatory fields in ruleset |
939
|
|
|
doi = models.CharField( |
940
|
|
|
max_length=255, |
941
|
|
|
help_text='Valid Digital Object Identifier') |
942
|
|
|
|
943
|
|
|
def __str__(self): |
944
|
|
|
return self.doi |
945
|
|
|
|
946
|
|
|
|
947
|
|
|
class Ontology(BaseMixin, models.Model): |
948
|
|
|
library_name = models.CharField( |
949
|
|
|
max_length=255, |
950
|
|
|
help_text='Each value must be unique', |
951
|
|
|
unique=True) |
952
|
|
|
|
953
|
|
|
library_uri = models.URLField( |
954
|
|
|
max_length=500, blank=True, null=True, |
955
|
|
|
help_text='Each value must be unique ' + |
956
|
|
|
'and with a valid URL') |
957
|
|
|
|
958
|
|
|
comment = models.CharField( |
959
|
|
|
max_length=255, blank=True, null=True) |
960
|
|
|
|
961
|
|
|
def __str__(self): |
962
|
|
|
return self.library_name |
963
|
|
|
|
964
|
|
|
class Meta: |
965
|
|
|
verbose_name_plural = "ontologies" |
966
|
|
|
|
967
|
|
|
|
968
|
|
|
class Submission(BaseMixin, models.Model): |
969
|
|
|
title = models.CharField( |
970
|
|
|
"Submission title", |
971
|
|
|
max_length=255, |
972
|
|
|
help_text='Example: Roslin Sheep Atlas') |
973
|
|
|
|
974
|
|
|
project = models.CharField( |
975
|
|
|
max_length=25, |
976
|
|
|
default="IMAGE", |
977
|
|
|
editable=False) |
978
|
|
|
|
979
|
|
|
description = models.CharField( |
980
|
|
|
max_length=255, |
981
|
|
|
help_text='Example: The Roslin Institute ' + |
982
|
|
|
'Sheep Gene Expression Atlas Project') |
983
|
|
|
|
984
|
|
|
# gene bank fields |
985
|
|
|
gene_bank_name = models.CharField( |
986
|
|
|
max_length=255, |
987
|
|
|
blank=False, |
988
|
|
|
null=False, |
989
|
|
|
help_text='example: CryoWeb') |
990
|
|
|
|
991
|
|
|
gene_bank_country = models.ForeignKey( |
992
|
|
|
'DictCountry', |
993
|
|
|
on_delete=models.PROTECT) |
994
|
|
|
|
995
|
|
|
# datasource field |
996
|
|
|
datasource_type = models.SmallIntegerField( |
997
|
|
|
"Data source type", |
998
|
|
|
choices=[x.value for x in DATA_TYPES], |
999
|
|
|
help_text='example: CryoWeb') |
1000
|
|
|
|
1001
|
|
|
datasource_version = models.CharField( |
1002
|
|
|
"Data source version", |
1003
|
|
|
max_length=255, |
1004
|
|
|
blank=False, |
1005
|
|
|
null=False, |
1006
|
|
|
help_text='examples: "2018-04-27", "version 1.5"') |
1007
|
|
|
|
1008
|
|
|
organization = models.ForeignKey( |
1009
|
|
|
'Organization', |
1010
|
|
|
on_delete=models.PROTECT, |
1011
|
|
|
help_text="Who owns the data") |
1012
|
|
|
|
1013
|
|
|
# custom fields for datasource |
1014
|
|
|
upload_dir = 'data_source/' |
1015
|
|
|
|
1016
|
|
|
# File will be stored to PROTECTED_MEDIA_ROOT + upload_to |
1017
|
|
|
# https://gist.github.com/cobusc/ea1d01611ef05dacb0f33307e292abf4 |
1018
|
|
|
uploaded_file = ProtectedFileField(upload_to=upload_dir) |
1019
|
|
|
|
1020
|
|
|
# when submission is created |
1021
|
|
|
created_at = models.DateTimeField(auto_now_add=True) |
1022
|
|
|
|
1023
|
|
|
# https://simpleisbetterthancomplex.com/tips/2016/05/23/django-tip-4-automatic-datetime-fields.html |
1024
|
|
|
updated_at = models.DateTimeField(auto_now=True) |
1025
|
|
|
|
1026
|
|
|
# a column to track submission status |
1027
|
|
|
status = models.SmallIntegerField( |
1028
|
|
|
choices=[x.value for x in STATUSES], |
1029
|
|
|
help_text='example: Waiting', |
1030
|
|
|
default=WAITING) |
1031
|
|
|
|
1032
|
|
|
# a field to track errors in UID loading. Should be blank if no errors |
1033
|
|
|
# are found |
1034
|
|
|
message = models.TextField( |
1035
|
|
|
null=True, |
1036
|
|
|
blank=True) |
1037
|
|
|
|
1038
|
|
|
owner = models.ForeignKey( |
1039
|
|
|
User, |
1040
|
|
|
on_delete=models.CASCADE) |
1041
|
|
|
|
1042
|
|
|
class Meta: |
1043
|
|
|
# HINT: can I put two files for my cryoweb instance? May they have two |
1044
|
|
|
# different version |
1045
|
|
|
unique_together = (( |
1046
|
|
|
"gene_bank_name", |
1047
|
|
|
"gene_bank_country", |
1048
|
|
|
"datasource_type", |
1049
|
|
|
"datasource_version", |
1050
|
|
|
"owner"),) |
1051
|
|
|
|
1052
|
|
|
def __str__(self): |
1053
|
|
|
return "%s (%s, %s)" % ( |
1054
|
|
|
self.gene_bank_name, |
1055
|
|
|
self.gene_bank_country.label, |
1056
|
|
|
self.datasource_version |
1057
|
|
|
) |
1058
|
|
|
|
1059
|
|
|
def get_uploaded_file_basename(self): |
1060
|
|
|
return os.path.basename(self.uploaded_file.name) |
1061
|
|
|
|
1062
|
|
|
def get_uploaded_file_path(self): |
1063
|
|
|
"""Return uploaded file path in docker container""" |
1064
|
|
|
|
1065
|
|
|
# this is the full path in docker container |
1066
|
|
|
fullpath = self.uploaded_file.file |
1067
|
|
|
|
1068
|
|
|
# get a string and quote fullpath |
1069
|
|
|
return shlex.quote(str(fullpath)) |
1070
|
|
|
|
1071
|
|
|
def get_absolute_url(self): |
1072
|
|
|
return reverse("submissions:detail", kwargs={"pk": self.pk}) |
1073
|
|
|
|
1074
|
|
|
def __status_not_in(self, statuses): |
1075
|
|
|
"""Return True id self.status not in statuses""" |
1076
|
|
|
|
1077
|
|
|
statuses = [x.value[0] for x in STATUSES if x.name in statuses] |
1078
|
|
|
|
1079
|
|
|
if self.status not in statuses: |
1080
|
|
|
return True |
1081
|
|
|
|
1082
|
|
|
else: |
1083
|
|
|
return False |
1084
|
|
|
|
1085
|
|
|
def can_edit(self): |
1086
|
|
|
"""Returns True if I can edit a submission""" |
1087
|
|
|
|
1088
|
|
|
# if there are no data I can't edit and do stuff |
1089
|
|
|
if self.animal_set.count() == 0 and self.sample_set.count() == 0: |
1090
|
|
|
return False |
1091
|
|
|
|
1092
|
|
|
# if I have data, apply the same condition of can_delete |
1093
|
|
|
return self.can_delete() |
1094
|
|
|
|
1095
|
|
|
def can_delete(self): |
1096
|
|
|
"""return True if I can delete the submission""" |
1097
|
|
|
|
1098
|
|
|
statuses = ['waiting', 'submitted'] |
1099
|
|
|
|
1100
|
|
|
return self.__status_not_in(statuses) |
1101
|
|
|
|
1102
|
|
|
def can_validate(self): |
1103
|
|
|
statuses = ['error', 'waiting', 'submitted', 'completed', 'ready'] |
1104
|
|
|
|
1105
|
|
|
return self.__status_not_in(statuses) |
1106
|
|
|
|
1107
|
|
|
def can_submit(self): |
1108
|
|
|
"""Return yes if I can submit a submission to BioSamples""" |
1109
|
|
|
|
1110
|
|
|
# I can submit only with READY status |
1111
|
|
|
if self.status == READY: |
1112
|
|
|
return True |
1113
|
|
|
|
1114
|
|
|
else: |
1115
|
|
|
return False |
1116
|
|
|
|
1117
|
|
|
|
1118
|
|
|
# --- Custom functions |
1119
|
|
|
|
1120
|
|
|
|
1121
|
|
|
# https://simpleisbetterthancomplex.com/tutorial/2016/07/22/how-to-extend-django-user-model.html#onetoone |
1122
|
|
|
# we will now define signals so our Person model will be automatically |
1123
|
|
|
# created/updated when we create/update User instances. |
1124
|
|
|
# Basically we are hooking the create_user_person and save_user_person |
1125
|
|
|
# methods to the User model, whenever a save event occurs. This kind of signal |
1126
|
|
|
# is called post_save. |
1127
|
|
|
# TODO: add default values when creating a superuser |
1128
|
|
|
@receiver(post_save, sender=User) |
1129
|
|
|
def create_user_person(sender, instance, created, **kwargs): |
1130
|
|
|
if created: |
1131
|
|
|
Person.objects.create(user=instance) |
1132
|
|
|
|
1133
|
|
|
|
1134
|
|
|
@receiver(post_save, sender=User) |
1135
|
|
|
def save_user_person(sender, instance, **kwargs): |
1136
|
|
|
instance.person.save() |
1137
|
|
|
|
1138
|
|
|
|
1139
|
|
|
# A method to truncate database |
1140
|
|
|
def truncate_database(): |
1141
|
|
|
"""Truncate image database""" |
1142
|
|
|
|
1143
|
|
|
logger.warning("Truncating ALL image tables") |
1144
|
|
|
|
1145
|
|
|
# call each class and truncate its table by calling truncate method |
1146
|
|
|
Animal.truncate() |
1147
|
|
|
DictBreed.truncate() |
1148
|
|
|
DictCountry.truncate() |
1149
|
|
|
DictRole.truncate() |
1150
|
|
|
DictSex.truncate() |
1151
|
|
|
DictSpecie.truncate() |
1152
|
|
|
DictUberon.truncate() |
1153
|
|
|
DictDevelStage.truncate() |
1154
|
|
|
DictPhysioStage.truncate() |
1155
|
|
|
Ontology.truncate() |
1156
|
|
|
Organization.truncate() |
1157
|
|
|
Person.truncate() |
1158
|
|
|
Publication.truncate() |
1159
|
|
|
Sample.truncate() |
1160
|
|
|
Submission.truncate() |
1161
|
|
|
|
1162
|
|
|
logger.warning("All cryoweb tables were truncated") |
1163
|
|
|
|
1164
|
|
|
|
1165
|
|
|
def truncate_filled_tables(): |
1166
|
|
|
"""Truncate filled tables by import processes""" |
1167
|
|
|
|
1168
|
|
|
logger.warning("Truncating filled tables tables") |
1169
|
|
|
|
1170
|
|
|
# call each class and truncate its table by calling truncate method |
1171
|
|
|
Animal.truncate() |
1172
|
|
|
Publication.truncate() |
1173
|
|
|
Sample.truncate() |
1174
|
|
|
Submission.truncate() |
1175
|
|
|
|
1176
|
|
|
logger.warning("All filled tables were truncated") |
1177
|
|
|
|
1178
|
|
|
|
1179
|
|
|
def uid_report(user): |
1180
|
|
|
"""Performs a statistic on UID database to find issues. require user as |
1181
|
|
|
request.user""" |
1182
|
|
|
|
1183
|
|
|
report = {} |
1184
|
|
|
|
1185
|
|
|
# get n_of_animals |
1186
|
|
|
report['n_of_animals'] = Animal.objects.filter( |
1187
|
|
|
owner=user).count() |
1188
|
|
|
|
1189
|
|
|
# get n_of_samples |
1190
|
|
|
report['n_of_samples'] = Sample.objects.filter( |
1191
|
|
|
owner=user).count() |
1192
|
|
|
|
1193
|
|
|
# merging dictionaries: https://stackoverflow.com/a/26853961 |
1194
|
|
|
# HINT: have they sense in a per user statistic? |
1195
|
|
|
report = {**report, **missing_terms()} |
1196
|
|
|
|
1197
|
|
|
return report |
1198
|
|
|
|
1199
|
|
|
|
1200
|
|
|
def missing_terms(): |
1201
|
|
|
"""Get informations about dictionary terms without ontologies""" |
1202
|
|
|
|
1203
|
|
|
# a list with all dictionary classes |
1204
|
|
|
dict_classes = [ |
1205
|
|
|
DictBreed, DictCountry, DictSpecie, DictUberon, DictDevelStage, |
1206
|
|
|
DictPhysioStage |
1207
|
|
|
] |
1208
|
|
|
|
1209
|
|
|
# get a dictionary to report data |
1210
|
|
|
report = {} |
1211
|
|
|
|
1212
|
|
|
for dict_class in dict_classes: |
1213
|
|
|
# get a queryset with missing terms |
1214
|
|
|
missing = dict_class.objects.filter(term=None) |
1215
|
|
|
|
1216
|
|
|
# set a key for report dictionary |
1217
|
|
|
key = "%s_without_ontology" % ( |
1218
|
|
|
dict_class._meta.verbose_name_plural.replace(" ", "_")) |
1219
|
|
|
|
1220
|
|
|
# track counts |
1221
|
|
|
report[key] = missing.count() |
1222
|
|
|
|
1223
|
|
|
# add the total value |
1224
|
|
|
total = dict_class.objects.count() |
1225
|
|
|
|
1226
|
|
|
# set a key for report dictionary |
1227
|
|
|
key = "%s_total" % ( |
1228
|
|
|
dict_class._meta.verbose_name_plural.replace(" ", "_")) |
1229
|
|
|
|
1230
|
|
|
# track counts |
1231
|
|
|
report[key] = total |
1232
|
|
|
|
1233
|
|
|
return report |
1234
|
|
|
|
1235
|
|
|
|
1236
|
|
|
# A method to discover is image database has data or not |
1237
|
|
|
def db_has_data(): |
1238
|
|
|
# Test only tables I read data to fill UID |
1239
|
|
|
if (Submission.objects.exists() and |
1240
|
|
|
Animal.objects.exists() and |
1241
|
|
|
Sample.objects.exists()): |
1242
|
|
|
return True |
1243
|
|
|
|
1244
|
|
|
else: |
1245
|
|
|
return False |
1246
|
|
|
|