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                import numpy as np  | 
            
            
                                                        
            
                                    
            
            
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                import torch  | 
            
            
                                                        
            
                                    
            
            
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                from ....data.image import Image  | 
            
            
                                                        
            
                                    
            
            
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                from ....data.subject import Subject  | 
            
            
                                                        
            
                                    
            
            
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                from ...spatial_transform import SpatialTransform  | 
            
            
                                                        
            
                                    
            
            
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                from .resample import Resample  | 
            
            
                                                        
            
                                    
            
            
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                class ToReferenceSpace(SpatialTransform):  | 
            
            
                                                        
            
                                    
            
            
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                    """Modify the spatial metadata so it matches a reference space.  | 
            
            
                                                        
            
                                    
            
            
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                    This is useful, for example, to set meaningful spatial metadata of a neural  | 
            
            
                                                        
            
                                    
            
            
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                    network embedding, for visualization or further processing such as  | 
            
            
                                                        
            
                                    
            
            
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                    resampling a segmentation output.  | 
            
            
                                                        
            
                                    
            
            
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                    Example:  | 
            
            
                                                        
            
                                    
            
            
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                    >>> import torchio as tio  | 
            
            
                                                        
            
                                    
            
            
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                    >>> image = tio.datasets.FPG().t1  | 
            
            
                                                        
            
                                    
            
            
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                    >>> embedding_tensor = my_network(image.tensor)  # we lose metadata here  | 
            
            
                                                        
            
                                    
            
            
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                    >>> embedding_image = tio.ToReferenceSpace.from_tensor(embedding_tensor, image)  | 
            
            
                                                        
            
                                    
            
            
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                    """  | 
            
            
                                                        
            
                                    
            
            
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                    def __init__(self, reference: Image, **kwargs):  | 
            
            
                                                        
            
                                    
            
            
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                        super().__init__(**kwargs)  | 
            
            
                                                        
            
                                    
            
            
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                        if not isinstance(reference, Image):  | 
            
            
                                                        
            
                                    
            
            
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                            raise TypeError('The reference must be a TorchIO image') | 
            
            
                                                        
            
                                    
            
            
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                        self.reference = reference  | 
            
            
                                                        
            
                                    
            
            
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                    def apply_transform(self, subject: Subject) -> Subject:  | 
            
            
                                                        
            
                                    
            
            
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                        for image in self.get_images(subject):  | 
            
            
                                                        
            
                                    
            
            
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                            new_image = build_image_from_reference(image.data, self.reference)  | 
            
            
                                                        
            
                                    
            
            
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                            image.set_data(new_image.data)  | 
            
            
                                                        
            
                                    
            
            
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                            image.affine = new_image.affine  | 
            
            
                                                        
            
                                    
            
            
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                        return subject  | 
            
            
                                                        
            
                                    
            
            
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                    @staticmethod  | 
            
            
                                                        
            
                                    
            
            
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                    def from_tensor(tensor: torch.Tensor, reference: Image) -> Image:  | 
            
            
                                                        
            
                                    
            
            
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                        """Build a TorchIO image from a tensor and a reference image."""  | 
            
            
                                                        
            
                                    
            
            
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                        return build_image_from_reference(tensor, reference)  | 
            
            
                                                        
            
                                    
            
            
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                def build_image_from_reference(tensor: torch.Tensor, reference: Image) -> Image:  | 
            
            
                                                        
            
                                    
            
            
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                    input_shape = np.array(reference.spatial_shape)  | 
            
            
                                                        
            
                                    
            
            
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                    output_shape = np.array(tensor.shape[-3:])  | 
            
            
                                                        
            
                                    
            
            
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                    downsampling_factor = input_shape / output_shape  | 
            
            
                                                        
            
                                    
            
            
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                    input_spacing = np.array(reference.spacing)  | 
            
            
                                                        
            
                                    
            
            
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                    output_spacing = input_spacing * downsampling_factor  | 
            
            
                                                        
            
                                    
            
            
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                    downsample = Resample(output_spacing, image_interpolation='nearest')  | 
            
            
                                                        
            
                                    
            
            
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                    reference = downsample(reference)  | 
            
            
                                                        
            
                                    
            
            
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                    class_ = reference.__class__  | 
            
            
                                                        
            
                                    
            
            
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                    result = class_(tensor=tensor, affine=reference.affine)  | 
            
            
                                                        
            
                                    
            
            
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                    return result  | 
            
            
                                                        
            
                                    
            
            
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